5167-80-6

Upstream product

• 104-12-1 p-chlorphenylisocyanate 
• 124-38-9 carbon dioxide 
• 106-47-8 4-chloro-aniline 
• 87179-05-3 (4-Chloro-phenyl)-carbamic acid 2-thiophen-2-yl-ethyl ester 
• 87179-04-2 N-(4-Chlor-phenyl)-carbamidsaeure-2- 
• 40119-93-5 N-p-Chlorophenyl-2-pyridylmethyl-carbamidsaeureester 

Downstream Products

• 940-36-3 (4-chloro-phenyl)-carbamic acid methyl ester 
• 499789-11-6 2-[3-(4-chlorophenylcarbamoyloxymethyl)-4-ethoxybenzyl]-tetrahydro-2-furancarboxylic acid 
• 106-47-8 4-chloro-aniline 
• 1219-99-4 N,N'-bis(4-chlorophenyl)urea 

Relevant academic research and scientific papers

The silver-mediated annulation of arylcarbamic acids and nitrosoarenes toward phenazines

A silver-mediated annulation between arylcarbamic acids and nitrosoarenes was developed, leading to phenazines in moderate to good yields with complexity and diversity. This procedure proceeded with the sequential ortho[sbnd] C[sbnd]H functionalization of arylcarbamic acids, insertion to nitroso group and decarboxylative annulation.

Mild and convenient synthesis of organic carbamates from amines and carbon dioxide using tetraethylammonium superoxide

A safe and simple method of preparing organic carbamates has been achieved from amines and carbon dioxide using tetraethylammonium superoxide generated in situ. Copyright Taylor & Francis Group, LLC.

THE KINETICS AND MECHANISM OF THE SPONTANEOUS HYDROLYSIS OF 4-CHLOROPHENYL ISOCYANATE IN DIETHYL ETHER SOLUTION

The kinetics of hydrolysis of 4-chlorophenyl isocyanate have been studied at low concentrations in diethyl ether solution at three temperatures.When the ratio : is sufficiently large the final organic product is 4-chloroaniline only, which arises from the loss of carbon dioxide from the initially formed carbamic acid, RNHCO2H.In the presence of a sufficient excess of water, the overall process comprises two consecutive first-order reactions , whose pseudo-first-order rate constants k1 and k2 both depend on the third power of the stoicheiometric water concentration.For the first reaction ΔH 22 kJ mol-1 and ΔS -202 J mol-1 K-1; for the second reaction ΔH = 22 +/-1 kJ mol-1 and ΔS = -216 +/-3 J mol-1 K-1.We interpret our results in terms of cyclic transition states involving trimeric water.Ours is the first kinetic investigation to detect the two-stage process of aniline formation.