51688-74-5Relevant academic research and scientific papers
Positron Emission Tomography Imaging of Neurotensin Receptor-Positive Tumors with68Ga-Labeled Antagonists: The Chelate Makes the Difference Again
Renard, Emma,Moreau, Mathieu,Bellaye, Pierre-Simon,Guillemin, Mélanie,Collin, Bertrand,Prignon, Aurélie,Denat, Franck,Goncalves, Victor
supporting information, p. 8564 - 8578 (2021/06/30)
Neurotensin receptor 1 (NTS1) is involved in the development and progression of numerous cancers, which makes it an interesting target for the development of diagnostic and therapeutic agents. A small molecule NTS1antagonist, named [
Flow-Assisted Synthesis: A Key Fragment of SR 142948A
Kitching, Matthew O.,Dixon, Olivia E.,Baumann, Marcus,Baxendale, Ian R.
supporting information, p. 6540 - 6553 (2017/09/13)
We report a series of multi-step flow operations to deliver an advanced hydrazine intermediate used in the assembly of the neurotensin modulator SR 142948A. Several new reactor configurations have enabled chemical transformations that would be otherwise difficult or dangerous to perform at scale. Overall the flow approach has allowed the preparation of kilogram quantities of the required hydrazine through a short and efficient route.
Substituted 1-phenyl-3-pyrazolecarboxamides active on neurotensin receptors, their preparation and pharmaceutical compositions containing them
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, (2008/06/13)
The invention relates to new substituted 1-phenyl-3-pyrazolecarboxamides having a great affinity for human neurotensin receptors, to a process for preparing them and to pharmaceutical compositions containing them as active principles. More particularly, this invention relates to the discovery that the affinity for neurotensin receptors, especially human neurotensin receptors, is increased by substituting the phenyl group of 1-phenyl-3-pyrazolecarboxamide compounds with particular groups.
