19246-04-9

Usage

Uses

Used in Pharmaceutical Industry:
2-ISOPROPYLACETANILIDE is used as an intermediate for the preparation of SR 142948 (S684350), which is an antagonist of NT1/NT2 receptors. The application reason for 2-ISOPROPYLACETANILIDE is to inhibit bile acid secretion, which can be beneficial in treating certain medical conditions related to bile acid imbalances or overproduction.

InChI:InChI=1/C11H15NO/c1-8(2)10-6-4-5-7-11(10)12-9(3)13/h4-8H,1-3H3,(H,12,13)

Upstream product

• 108-24-7 acetic anhydride 
• 643-28-7 2-isopropylaniline 
• 75-36-5 acetyl chloride 
• 98-82-8 Isopropylbenzene 

Downstream Products

• 51688-72-3 N-(4-bromo-2-isopropylphenyl)acetamide 
• 1070790-69-0 N-hydroxymethyl-N-(2-isopropylphenyl)acetamide 
• 1207442-29-2 2-isopropyl-N-[(3E)-3-(2-isopropylphenyl)imino-2-[N-(2-isopropylphenyl)-C-methyl-carbonimidoyl]-1-methyl-but-1-enyl]aniline 
• 1427716-68-4 (E,E)-2,5-bis[2-(3-isopropyl-4-N,N-diethylaminophenyl)ethenyl]pyrazine 
• 31539-91-0 N-(2-isopropyl-4-nitrophenyl)acetamide 
• 103151-02-6 4-isopropyl-1,3-dihydro-benzimidazol-2-one 

Relevant academic research and scientific papers

Flow-Assisted Synthesis: A Key Fragment of SR 142948A

We report a series of multi-step flow operations to deliver an advanced hydrazine intermediate used in the assembly of the neurotensin modulator SR 142948A. Several new reactor configurations have enabled chemical transformations that would be otherwise difficult or dangerous to perform at scale. Overall the flow approach has allowed the preparation of kilogram quantities of the required hydrazine through a short and efficient route.

Positron Emission Tomography Imaging of Neurotensin Receptor-Positive Tumors with68Ga-Labeled Antagonists: The Chelate Makes the Difference Again

Neurotensin receptor 1 (NTS1) is involved in the development and progression of numerous cancers, which makes it an interesting target for the development of diagnostic and therapeutic agents. A small molecule NTS1antagonist, named [

Mild and efficient palladium-catalyzed direct trifluoroethylation of aromatic systems by C-H activation

The introduction of trifluoroalkyl groups into aromatic molecules is an important transformation in the field of organic and medicinal chemistry. However, the direct installation of fluoroalkyl groups onto aromatic molecules still represents a challenging and highly demanding synthetic task. Herein, a simple trifluoroethylation process that relies on the palladium-catalyzed C-H activation of aromatic compounds is described. With the utilization of a highly active trifluoroethyl(mesityl)iodonium salt, the developed catalytic method enables the first highly efficient and selective trifluoroethylation of aromatic compounds. The robust catalytic procedure provides the desired products in up to 95 % yield at 25 °C in 1.5 to 3 hours and tolerates a broad range of functional groups. The utilization of hypervalent reagents opens new synthetic possibilities for direct alkylations and fluoroalkylations in the field of transition-metal-catalyzed C-H activation.

Synthesis and Herbicidal Activity of Triketone-Quinoline Hybrids as Novel 4-Hydroxyphenylpyruvate Dioxygenase Inhibitors

4-Hydroxyphenylpyruvate dioxygenase (EC 1.13.11.27, HPPD) is one of the most important targets for herbicide discovery. In the search for new HPPD inhibitors with novel scaffolds, triketone-quinoline hybrids were designed and subsequently optimized on the basis of the structure-activity relationship (SAR) studies. Most of the synthesized compounds displayed potent inhibition of Arabidopsis thaliana HPPD (AtHPPD), and some of them exhibited broad-spectrum and promising herbicidal activity at the rate of 150 g ai/ha by postemergence application. Most promisingly, compound III-l, 3-hydroxy-2-(2-methoxy-7-(methylthio)quinoline-3-carbonyl)cyclohex-2-enone (Ki = 0.009 ～M, AtHPPD), had broader spectrum of weed control than mesotrione. Furthermore, compound III-l was much safer to maize at the rate of 150 g ai/ha than mesotrione, demonstrating its great potential as herbicide for weed control in maize fields. Therefore, triketone-quinoline hybrids may serve as new lead structures for novel herbicide discovery.

Donor-substituted distyrylpyrazines: Influence of steric congestion on UV-Vis absorption and fluorescence

Di(p-aminostyryl)pyrazines with voluminous substituents on the nitrogen and in the adjacent positions were prepared via twofold aldol condensation. Absorption and emission spectra are influenced by increasing steric hindrance because the orbital overlap between nitrogen and π-system is modulated by voluminous groups. Strong solvatochromism of the fluorescence and huge Stokes shifts result from amplified donor-acceptor interaction in the excited state. Protonation occurs at the terminal amino groups first, followed by protonation of the central pyrazine. With increasing strength of acid, absorption and emission spectra are first shifted to the blue followed by a redshift. Copyright

Substituted 2-arylimino heterocycles and compositions containing them, for use as progesterone receptor binding agents

This invention relates to 2-arylimino heterocycles, including 2-arylimino-1,3-thiazolidines, 2-arylimino-2,3,4,5-tetrahydro-1,3-thiazines, 2-arylimino-1,3-thiazolidin-4-ones, 2-arylimino-1,3-thiazolidin-5-ones, and 2-arylimino-1,3-oxazolidines, and their use in modulating progesterone receptor mediated processes, and pharmaceutical compositions for use in such therapies.