51739-63-0

Usage

Uses

N1,N2-Dimethylglycinamide HCl

Upstream product

• 105-39-5 chloroacetic acid ethyl ester 
• 74-89-5 methylamine 
• 144332-55-8 tert-butyl methyl(2-(methylamino)-2-oxoethyl)carbamate 

Downstream Products

• 49756-06-1 N-Methyl-N-methylcarbamoylmethyl-5-nitro-isophthalamic acid methyl ester 
• 124052-33-1 N-methyl-N-(2,4-dinitrophenyl)glycine methylamide 

Relevant academic research and scientific papers

Copper(II) complexes with N′-methylsarcosinamide selective for human bladder cancer cells

Two copper(II) complexes, [CuCl2(SarMeam)2] · H2O (1) and [Cu(NO3)2(SarMeam)2] (2) were obtained by reactions of N′-methylsarcosinamide (SarMeam) with copper(II) chloride and copper(II) nitrate in aqueous solutions. The complexes were characterized by X-ray crystallography, IR and UV-Vis spectroscopy, thermal analysis (TG-DTA) and DFT calculations. The octahedral coordination environments around the copper(II) ions in complexes 1 and 2 consisted of two N,O-bidentate N′-methylsarcosinamide ligands and two chloride or nitrate ions, respectively, forming trans isomers. The [CuCl(H2O)(SarMeam)2]+ and [Cu(H2O)2(SarMeam)2]2+ species formed upon dissolution of 1 by successive substitution of coordinated chloride ions with water molecules, while dissolution of 2 led exclusively to the formation of [Cu(H2O)2(SarMeam)2]2+. [Cu(OH)(H2O)(SarMeam)2]+ species formed in basic solutions by deprotonation of coordinated ligands and then transformed to a planar [Cu(SarMeam?H)2]. Complexes 1 and 2 decomposed in highly acidic or basic solutions, giving [Cu(H2O)6]2+ or Cu(OH)2, respectively. The water-soluble complexes 1 and 2 were biologically evaluated and tested on human bladder cancer T24 and UM-UC-3 cell lines and a panel of Gram-negative and Gram-positive bacteria. They showed excellent potency towards human bladder cancer T24 cell line and no activity against bacterial strains. At the same time no toxicity was noticed on normal human cells, as observed by the cell viability and comet assay on peripheral blood leukocytes.

A General Strategy to Enhance Donor-Acceptor Molecules Using Solvent-Excluding Substituents

While organic donor-acceptor (D-A) molecules are widely employed in multiple areas, the application of more D-A molecules could be limited because of an inherent polarity sensitivity that inhibits photochemical processes. Presented here is a facile chemical modification to attenuate solvent-dependent mechanisms of excited-state quenching through addition of a β-carbonyl-based polar substituent. The results reveal a mechanism wherein the β-carbonyl substituent creates a structural buffer between the donor and the surrounding solvent. Through computational and experimental analyses, it is demonstrated that the β-carbonyl simultaneously attenuates two distinct solvent-dependent quenching mechanisms. Using the β-carbonyl substituent, improvements in the photophysical properties of commonly used D-A fluorophores and their enhanced performance in biological imaging are shown.