5174-87-8

Usage

InChI:InChI=1/C11H10N2O/c1-7-10(8(2)14)6-9-4-3-5-12-11(9)13-7/h3-6H,1-2H3

Upstream product

• 7521-41-7 2-Aminonicotinaldehyde 
• 123-54-6 acetylacetone 

Downstream Products

• 119496-42-3 (E)-1-(2-Methyl-[1,8]naphthyridin-3-yl)-3-p-tolyl-propenone 
• 119496-44-5 (E)-3-(4-Chloro-phenyl)-1-(2-methyl-[1,8]naphthyridin-3-yl)-propenone 
• 119496-45-6 (E)-3-(2-Hydroxy-phenyl)-1-(2-methyl-[1,8]naphthyridin-3-yl)-propenone 
• 119496-48-9 (E)-1-(2-Methyl-[1,8]naphthyridin-3-yl)-3-(3-nitro-phenyl)-propenone 
• 1632038-88-0 4'-methyl-3-(2-methyl-1,8-naphthyridin-3-yl)-5-(piperidin-1-yl)biphenyl-4-carbonitrile 
• 1632038-87-9 4'-methoxy-3-(2-methyl-1,8-naphthyridin-3-yl)-5-(piperidin-1-yl)biphenyl-4-carbonitrile 
• 1632038-86-8 4'-bromo-3-(2-methyl-1,8-naphthyridin-3-yl)-5-(piperidin-1-yl)biphenyl-4-carbonitrile 
• 1632038-85-7 4'-chloro-3-(2-methyl-1,8-naphthyridin-3-yl)-5-(piperidin-1-yl)biphenyl-4-carbonitrile 
• 1632038-84-6 3-(2-methyl-1,8-naphthyridin-3-yl)-5-piperidin-1-ylbiphenyl-4-carbonitrile 
• 119496-66-1 2-Methoxy-4-[5-(2-methyl-[1,8]naphthyridin-3-yl)-2-phenyl-3,4-dihydro-2H-pyrazol-3-yl]-phenol 
• 119496-68-3 2-Methyl-3-[5-(3-nitro-phenyl)-1-phenyl-4,5-dihydro-1H-pyrazol-3-yl]-[1,8]naphthyridine 
• 119496-67-2 Dimethyl-{4-[5-(2-methyl-[1,8]naphthyridin-3-yl)-2-phenyl-3,4-dihydro-2H-pyrazol-3-yl]-phenyl}-amine 
• 119496-60-5 3-[5-(2-Methoxy-phenyl)-1-phenyl-4,5-dihydro-1H-pyrazol-3-yl]-2-methyl-[1,8]naphthyridine 
• 119496-61-6 3-[5-(4-Methoxy-phenyl)-1-phenyl-4,5-dihydro-1H-pyrazol-3-yl]-2-methyl-[1,8]naphthyridine 

Relevant academic research and scientific papers

Synthesis method of 1,8-naphthyridine derivative

The invention belongs to the technical field of organic synthesis, and particularly relates to a synthesis method of a 1,8-naphthyridine derivative. The synthesis method comprises the following steps: under the protection of nitrogen, subjecting 2-amino-3

A mild synthesis of substituted 1,8-naphthyridines

A greener method for the synthesis of substituted 1,8-naphthyridines has been developed, which is supported by reaction metric analysis. Using 2-aminonicotinaldehyde as a starting material with a variety of carbonyl reaction partners, the Friedl?nder reac

ZrOClinf2/inf.8Hinf2/infO catalyzed solvent-free Friedlander synthesis of 1,8-naphthyridines

ZrOClinf2/inf.8Hinf2/infO catalyzed Friedlander condensation of 2-Aminonicotinaldehyde 1 with carbonyl compounds containing-methylene group 2 has been achieved in solvent-free grinding conditions to give 1,8-naphthyridines 3. The yields are very good and

Cecl3.7H2O catalyzed Friedlander synthesis of 1,8-naphthyridines under solvent-free grinding conditions

CeCl3.7H2O catalyses the Friedlander condensation of 2-aminonicotinaldehyde 1 with varius carbonyl compounds containing α-methylene group 2 in solvent-free grinding conditions to afford the corresponding 1,8-naphthyridines 3. The rea

Green approach for the efficient synthesis of 1,8-naphthyridines promoted by citric acid

Citric acid catalyzed Friedlander condensation of 2-aminonicotinaldehyde 1 with various carbonyl compounds containing α-methylene group 2 has been achieved under neat conditions at 100° to give the corresponding 1,8-naphthyridines 3. The products are obta

Eco-friendly catalytic systems based on carbon-supported magnesium oxide materials for the friedl?nder condensation

Carbon-supported MgO materials are excellent and sustainable catalysts for the synthesis of N-containing heterocyclic compounds by the Friedl?nder condensation under mild, solvent-free conditions. The results reported herein indicate that MgO is the most active catalytic species that accelerates the reaction compared with the catalytic behavior observed for the carbon material Norit RX3. On the basis of DFT calculations, a reaction mechanism that involves dual activation of the reacting structures by the catalyst is proposed. Oxide, outside: MgO supported on carbon is able to catalyze the synthesis of interesting N-containing heterocyclic compounds efficiently under mild conditions. MgO on the carbon surface is responsible for the catalytic behavior. These carbon materials are environmentally friendly catalysts for the Friedl?nder reaction.

A simple and efficient protocol for the synthesis of 1,8- naphthyridines using sodium hydrogensulfate on silica gel under solvent free condition

A simple and efficient method for the synthesis of 1,8-naphthyridines using silicagel supported sodium hydrogen sulfate as reusable eco-friendly catalyst via Friedlander annulation under solvent-free conditions is described. A series of functionalized der

Potassium triiodide catalyzed Friedlander synthesis of 1,8-naphthyridines in aqueous media

Potassium triiodide catalyses the Friedlander condensation of 2-aminonicotinaldehyde 1 with carbonyl compounds containing α-methylene group 2 in aqueous media to afford 1,-naphthyridines 3 in high yields.

Microwave-assisted solvent-free Friedlander synthesis of 1,8-naphthyridines using ammonium acetate as catalyst

The microwave enhanced synthesis of 1,8-naphthyridines 3 is achieved rapidly and in good yield via the Friedlander condensation of 2-aminonicotinaldehyde 1 with carbonyl compounds containing α-methylene group 2 in the presence of ammonium acetate.

Microwave induced Friedlander condensation - A facile synthesis of 1,8-naphthyridines

A simple and efficient method has been developed for the rapid synthesis of 1,8-naphthyridines 3 from 2-aminonicotinaldehyde 1 and active methylene compounds 2 in methanol in the presence of a catalytic amount of piperidine in unmodified domestic microwav