51759-50-3Relevant academic research and scientific papers
DBSA mediated chemoselective synthesis of 2-substituted benzimidazoles in aqueous media
Kumar, Vikash,Khandare, Dipratn G.,Chatterjee, Amrita,Banerjee, Mainak
, p. 5505 - 5509 (2013)
An efficient synthetic method has been developed for the facile synthesis of 2-substituted benzimidazoles in organized aqueous media in the presence of a surfactant (viz. DBSA) as catalyst and I2 as co-catalyst. The method described has the advantages of operational simplicity, excellent yields, high chemoselectivity, and clean and green reaction profile.
Synthesis and evaluation of novel bacterial rRNA-binding benzimidazoles by mass spectrometry
He, Yun,Yang, Jun,Wu, Baogen,Robinson, Dale,Sprankle, Kelly,Kung, Pei-Pei,Lowery, Kristin,Mohan,Hofstadler, Steve,Swayze, Eric E.,Griffey, Rich
, p. 695 - 699 (2007/10/03)
A series of novel benzimidazoles were efficiently synthesized using both solution- and solid-phase chemistry. These compounds were found to bind to the bacterial 16S ribosomal RNA A-site with micromolar affinities using unique mass spectrometry-based assays.
Synthesis and structure-activity relationships of some 2,5- disubstituted benzoxazoles and benzimidazoles as antimicrobial agents
Sener,Yalcin,Temiz,Oren,Akin,Ucarturk
, p. 99 - 103 (2007/10/03)
The synthesis of a new series of 2,5-disubstitutedbenzoxazoles 5a-e, and 2,5-disubstituted-benzimidazoles 6a-h are described in order to determine their antimicrobial activities and feasible structure-activity relationships (SAR). The synthesized compound
