51765-67-4Relevant academic research and scientific papers
Palladium-Catalyzed Mizoroki-Heck Reaction of Nitroarenes and Styrene Derivatives
Okita, Toshimasa,Asahara, Kitty K.,Muto, Kei,Yamaguchi, Junichiro
, p. 3205 - 3208 (2020)
We have developed a Mizoroki-Heck reaction of nitroarenes with alkenes under palladium catalysis. The use of a Pd/BrettPhos catalyst promoted the alkenylation, whereas other catalysts led to a decrease in the product yield. In addition to nitroarenes, nitroheteroarenes were also applicable to the present reaction. The combination of a nucleophilic aromatic substitution (SNAr) with the denitrative alkenylation produced a multifunctionalized arene in a one-pot operation.
Spectral and crystallographic study of pyridinic analogues of nimesulide: Determination of the active form of methanesulfonamides as COX-2 selective inhibitors
Julémont, Fabien,De Leval, Xavier,Michaux, Catherine,Damas, Jacques,Charlier, Caroline,Durant, Fran?ois,Pirotte, Bernard,Dogné, Jean-Michel
, p. 5182 - 5185 (2007/10/03)
Compound 7, N-(3-phenoxy-4-pyridinyl)trifluoromethanesulfonamide, showed in vitro (whole blood assay) a strong inhibitory activity on the two cyclooxygenase (COX) enzymes (IC50(COX1) = 2.2 μM and IC50(COX-2) = 0.4 μM), being more act
