51767-61-4Relevant academic research and scientific papers
Silver-Promoted Direct Phosphorylation of Bulky C(sp2)-H Bond to Build Fully Substituted β-Phosphonodehydroamino Acids
Cao, Hao-Qiang,Liu, Hao-Nan,Liu, Zhe-Yuan,Qiao, Baokun,Zhang, Fa-Guang,Ma, Jun-An
, p. 6414 - 6419 (2020/09/02)
A general and practical cross-dehydrogenative coupling protocol between readily available trisubstituted α,β-dehydro α-amino carboxylic esters and H-phosphites is described. This C(sp2)-H phosphorylation reaction proceeds with absolute Z-selectivity promoted by silver salt in a radical relay manner. The bulky tetrasubstituted β-phosphonodehydroamino acids were obtained in grams and added new modules to the toolkit for peptide modifications.
A simple and efficient method for the synthesis of Erlenmeyer azlactones
Conway, Philip A.,Devine, Kevin,Paradisi, Francesca
experimental part, p. 2935 - 2938 (2009/05/30)
We have recently developed a novel and efficient method for synthesising Erlenmeyer azlactones under mild and rapid conditions. The reaction is performed by reacting 2-phenyl-5-oxazolone with an aldehyde in dichloromethane using alumina as a catalyst. The materials react instantly at room temperature, negating the need for high temperatures and long reaction times. We have successfully used this method for both aliphatic, aromatic and heteroaromatic aldehydes, synthesising previously unmade Erlenmeyer azlactones in moderate to high yields.
Cycloaddition of 4,5-dihydrooxazol-5-one derivatives to 4-methylbenzene-1,2-dithiol
Tikdari,Fozooni,Vazee,Hamidian
, p. 1046 - 1049 (2007/10/03)
Reactions of 4,5-dihydrooxazol-5-one derivatives with 4-methylbenzene-1,2- dithiol in the presence of triethylamine includes nucleophilic attack by the thiol group on the carbonyl carbon atom in the oxazole ring, followed by opening of the latter and recy
