63196-29-2Relevant academic research and scientific papers
2,6-diamino -3,5-di-cyano pyridine compounds one-pot synthesis
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Paragraph 0063-0065, (2016/11/21)
The invention relates to one-pot synthesis of a 2,6-diamino-3,5-dicyanopyridine compound, and belongs to the field of a synthesis technology. A reaction general formula in preparation is as shown in the specification, wherein R1 represents an aliphatic co
A practical synthesis of substituted 2,6-diaminopyridines via microwave-assisted copper-catalyzed amination of halopyridines
Mastalir, Matthias,Rosenberg, Egon E.,Kirchner, Karl
, p. 8104 - 8110 (2015/12/30)
A microwave assisted copper-catalyzed amination protocol is reported utilizing a series of 2,6-dihalo- and 2-amino-6-halo pyridine precursors. Using this procedure, selective substitution of one or two halogens by aryl or alkylamines was achieved within 2-6 h with temperatures between 80 and 225 °C affording 2,6-diaminopyridines in good to excellent isolated yields. The reaction allows easy variation between educts and different N-substitutions. The target compounds are valuable precursors for the synthesis of bis-phosphorylated 2,6-diaminopyridines which are used as PNP pincer ligands in transition metal complexes.
Microwave irradiation-assisted amination of 2-chloropyridine derivatives with amide solvents
Samadi, Abdelouahid,Silva, Daniel,Chioua, Mourad,Carreiras, Maria Do Carmo,Marco-Contelles, Jose
experimental part, p. 2859 - 2869 (2011/09/12)
A simple, quick, and high-yielding microwave-assisted synthesis of 2-(N,Ndimethyl) amine- and 2-aminopyridine derivatives is reported here for the first time in the reaction of 2-chloro substituted pyridines with amide solvents such as dimethylformamide or formamide, without transition-metal catalysts. Taylor & Francis Group, LLC.
