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Glycine, N-methyl-N-(2-nitrobenzoyl)-, also known as N-methyl-N-(2-nitrobenzoyl)glycine or MNBG, is a chemical compound with the molecular formula C10H10N2O4. It is a derivative of glycine, an amino acid, where the carboxyl group is esterified with 2-nitrobenzoyl and the amino group is methylated. MNBG is a potent inhibitor of the enzyme dihydrofolate reductase (DHFR), which plays a crucial role in the synthesis of DNA and RNA. Glycine, N-methyl-N-(2-nitrobenzoyl)- has been studied for its potential use in cancer chemotherapy and as a research tool to understand the mechanism of DHFR inhibition. Its chemical structure and properties make it a valuable compound in the field of medicinal chemistry and drug development.

5177-51-5

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5177-51-5 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 5177-51-5 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 5,1,7 and 7 respectively; the second part has 2 digits, 5 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 5177-51:
(6*5)+(5*1)+(4*7)+(3*7)+(2*5)+(1*1)=95
95 % 10 = 5
So 5177-51-5 is a valid CAS Registry Number.

5177-51-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 15, 2017

Revision Date: Aug 15, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-[methyl-(2-nitrobenzoyl)amino]acetic acid

1.2 Other means of identification

Product number -
Other names Glycine,N-methyl-N-(2-nitrobenzoyl)

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:5177-51-5 SDS

5177-51-5Downstream Products

5177-51-5Relevant academic research and scientific papers

Non-peptidic inhibitors of human neutrophil elastase: The design and synthesis of sulfonanilide-containing inhibitors

Imaki, Katsuhiro,Okada, Takanori,Nakayama, Yoshisuke,Nagao, Yuuki,Kobayashi, Kaoru,Sakai, Yasuhiro,Mohri, Tetsuya,Amino, Takaaki,Nakai, Hisao,Kawamura, Masanori

, p. 2115 - 2134 (2007/10/03)

A novel series of pivaloyloxy benzene derivatives has been identified as potent and selective human neutrophil elastase (HNE) inhibitors. Convergent syntheses were developed in order to identify the inhibitors which are intravenously effective in an animal model. A compound of particular interest is the sulfonanilide-containing analogues. Structure-activity relationships are discussed. Structural requirements for metabolic stabilization are also discussed.

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