51779-51-2Relevant academic research and scientific papers
Lactonization of C(sp2)—H Bonds in Enamides with CO2
Zhang, Zhen,Zhu, Chun-Jun,Miao, Meng,Han, Jie-Lian,Ju, Tao,Song, Lei,Ye, Jian-Heng,Li, Jing,Yu, Da-Gang
, p. 430 - 436 (2018/04/05)
Herein, we report a novel synthesis of 1,3-oxazin-6-ones from enamides with CO2 through C—H carboxylation and one-pot cyclization. This transition-metal-free and redox-neutral process features broad substrate scope, good functional group tolerance and facile product derivatization. The nucleophilic attack to CO2 from the electron-rich alkene is demonstrated for this reaction.
1,3-Oxazines and Related Compounds. XII. Facile Synthesis of 2,4-Disubstituted 6H-1,3-Oxazin-6-ones
Yamamoto, Yutaka,Morita, Yasuo,Minami, Keiko
, p. 1980 - 1986 (2007/10/02)
A convenient method for synthesis of 2,4-disubstituted 6H-1,3-oxazin-6-ones (8) was developed.Acylaminoalkylidene-1,3-dioxane-4,6-diones (5a-l), which were prepared from N-acylimidates (3a-l) and Meldrum's acid (4), readily underwent thermolysis upon heating, leading to a variety of 2,4-disubstituted 6H-1,3-oxazin-6-ones (8a-l).Keywords - 6H-1,3-oxazin-6-one; Meldrum's acid; acylaminoalkylidene-1,3-dioxane-4,6-dione; N-acylimidate; thermolysis
