51779-52-3Relevant academic research and scientific papers
Acylations des cetones α-β-ethyleniques catalysees par les acides sulfoniques : synthese concomitante de sels de pyrylium et de dihydro-2,3-pyrones-4
Graindorge, Herve,Roussel, Christian
, p. 454 - 458 (2007/10/02)
The acylation of α,β-ethylenic ketones by carboxylic acid anhydrides catalyzed by sulfonic acids lead to the expected unsymmetrical pyrylium salts. 2,3-Dihydro-pyran-4-ones are also formed.The respective yields depend upon the alkyl substituents of the starting material.
Synthese de tetraalkyl-1,3,6,8 naphtyridines-2,7 dissymetriques
Erre, Claude H.,Roussel, Christian
, p. 454 - 457 (2007/10/02)
Ketonic compounds such as 4-hydroxy-4-methyl-2-pentanone, 4-methoxy-4-methyl-2-pentanone, 2-methyl-2-hexene-4-one and 2,5-dimethyl-2-hexene-4-one have been acylated by propionyl chloride, isobutyrylchloride, acetylchloride under Friedel-Crafts conditions and treated with liquid ammonia to give new 1,3,6,8-tetraalkyl-2,7-naphthyridines 8 and 9, together with 2,6-dialkyl-4-methyl-pyridine 7.Whatever the steric requirement of acylating agent the alkyl substituent already attached to the ketonic starting material is preferentially located in position 3 of the naphthyridine nucleus.Symmetrical 2,6-dialkyl-4-methyl pyridines 1 and symmetrical 1,3,6,8-tetraalkyl-2,7-naphthyridines which are evidenced, come from deacylation of the starting material followed by di- or tetraacylation of the resulting isobutene.
