51784-59-9Relevant academic research and scientific papers
TETRAHYDROPYRIDINE DERIVATIVES AS DOPAMINE RECEPTOR SUBTYPE LIGANDS
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, (2008/06/13)
A class of 1,2,3,6-tetrahydropyridine derivatives, substituted in the 4-position by a fused bicyclic heteroaromatic moiety and in the 1-position by an optionally substituted benzyl moiety, are ligands for dopamine receptor subtypes within the body, in particular the D 4 subtype, and are therefore useful in the treatment and/or prevention of disorders of the dopamine system, in particular schizophrenia or depression.
4-Heterocyclyl tetrahydropyridines as selective ligands for the human dopamine D4 receptor.
Haworth,Harrison,Kulagowski,Leeson,Owens,Ridgill,Teall,Fielding,Chapman,Emms,Marwood,Patel,Moss
, p. 2211 - 2216 (2007/10/03)
A series of 1,2,3,6-tetrahydropyridines 3 were synthesised, which resulted in selective high affinity dopamine D4 ligands. The SAR of heterocyclic replacements and aromatic substitution was investigated, leading to compounds of nanomolar bindin
Substituted 3,6-dihydro-1(2H)-pyridinylpropanols
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, (2008/06/13)
Compounds having the formula STR1 and the pharmaceutically acceptable salts thereof, wherein R1 is alkanoyl; R2 is STR2 AND N IS 0, 1 OR 2; HAVE USEFUL HYPOTENSIVE PROPERTIES.
