51786-15-3

Usage

InChI:InChI=1/C11H15NO4S2/c1-17-8-7-10(11(13)14)12-18(15,16)9-5-3-2-4-6-9/h2-6,10,12H,7-8H2,1H3,(H,13,14)/p-1/t10-/m1/s1

Upstream product

• 63-68-3 L-methionine 
• 98-09-9 benzenesulfonyl chloride 
• 59-51-8 DL-methionine 

Downstream Products

• 85828-34-8 (S)-1-(Methylthio)-3-<(phenylsulfonyl)amino>-4-octanone 
• 1380243-44-6 C₁₆H₁₆F₃NO₃S 
• 1380243-33-3 C₁₇H₁₈F₃NO₂S₂ 
• 1380243-21-9 C₁₁H₁₅NO₂S₂ 
• 1380298-37-2 C₁₂H₁₉NO₅S₃ 
• 1380243-50-4 C₂₂H₁₉F₆N₅O₃S 
• 1380243-47-9 C₁₆H₁₄F₃NO₄S 
• 1380243-14-0 C₁₁H₁₇NO₃S₂ 
• 93341-39-0 2-(1'-benzenesulphonylamino-3'-methylmercapto)propyl-benzimidazole 
• 85828-35-9 (S)-6-(Methylthio)-4-<(phenylsulfonyl)amino>-3-hexenone 

Relevant academic research and scientific papers

Design, synthesis, molecular docking, antimicrobial, and antioxidant activities of new phenylsulfamoyl carboxylic acids of pharmacological interest

The research explores the facile synthesis of some new phenylsulfamoyl carboxylic acids, their molecular docking, antimicrobial, and antioxidant activities. The procedure involved the mild reaction of amino acids with benzenesulfonyl chloride in a medium

New carboxamides bearing benzenesulphonamides: Synthesis, molecular docking and pharmacological properties

Ten new derivatives of benzenesulphonamide bearing carboxamide functionality were synthesized and investigated for their in vitro antimicrobial, antioxidant and in vivo anti-inflammatory activities. Compound 9d inhibited carrageenan induced rat-paw oedema

INTERMEDIATES OF SITAGLIPTIN AND PREPARATION PROCESS THEREOF

Disclosed are intermediates of Sitagliptin, a preparation process thereof, and a process for synthesizing Sitagliptin using these intermediates. Sitagliptin is synthesized by using chiral amino compounds as a raw material, without having to build a chiral center with a chiral asymmetric catalytic hydrogenation, and high-pressure hydrogenation is avoided.

INTERMEDIATES OF SITAGLIPTIN AND PREPARATION PROCESS THEREOF

Disclosed are intermediates of Sitagliptin, a preparation process thereof, and a process for synthesizing Sitagliptin using these intermediates. Sitagliptin is synthesized by using chiral amino compounds as a raw material, without having to build a chiral center with a chiral asymmetric catalytic hydrogenation, and high-pressure hydrogenation is avoided.

α-Amino Acids as Chiral Educts for Asymmetric Products. Aminoacylation of Metallo Alkyls and Alkenyls

α-Amino acids have been developed as educts for the preparation of optically pure α-amino aliphatic ketones.The amino group of the L-amino acid was first blocked as a suitable acyl derivative, namely, acetyl, benzoyl, ethoxycarbonyl, or benzenesulfonyl.Then the lithium carboxylate was formed and treated with alkyl- and alkenyllithium or Grignard reagents.Thus butyl, allyl, and vinyl organometallics were added to the lithium carboxylates of L-α-N-substituted alanine, valine, O-benzyltyrosine, methionine, serine, and ε-(ethoxycarbonyl)lysine to yield the corresponding optically pure ketones, protected as amides, sulfonamides, or carbamates.