517867-87-7Relevant academic research and scientific papers
Synthesis and evaluation of potent pyrrolidine H3 antagonists
Vasudevan, Anil,Conner, Scott E.,Gentles, Robert G.,Faghih, Ramin,Liu, Huaqing,Dwight, Wesley,Ireland, Lynne,Kang, Chae Hee,Esbenshade, Timothy A.,Bennani, Youssef L.,Hancock, Arthur A.
, p. 3055 - 3058 (2007/10/03)
The synthesis and biological evaluation of novel antagonists of the rat H3 receptor are described. These compounds differ from prototypical H3 antagonists in that they do not contain an imidazole moiety, but rather a substituted aminopyrrolidine moiety. A systematic modification of the substituents on the aminopyrrolidine ring was performed using pre-formatted precursor sets, where applicable, to afford several compounds with high affinity and selectivity for the H3 receptor.
