51787-80-5

Upstream product

• 3874-54-2 4-(4-fluorophenyl)-4-oxo-n-butyl chloride 
• 460-00-4 1-Bromo-4-fluorobenzene 
• 352-13-6 4-flourophenylmagnesium bromide 

Downstream Products

• 3311-94-2 4,4-bis(4-fluorophenyl)-3-butenyl chloride 
• 77294-02-1 2-[4,4-Bis-(4-fluoro-phenyl)-but-3-enyl]-1,2,3,4,6,7,12,12a-octahydro-pyrazino[1',2':1,6]pyrido[3,4-b]indole 

Relevant academic research and scientific papers

Agents Acting on CNS: Part XXX - Synthesis of 2-Substituted 1,2,3,4,6,7,12,12a-Octahydropyrazinopyrido-indoles

A number of 2-substituted pyrazinopyridoindoles (3,6-12) have been prepared by the condensation of 1,2,3,4,6,7,12,12a-octahydropyrazinopyridoindole (1) with appropriate halogen compounds.Treatment of 1 with ethylene oxide gives 4 which on condensation with p-fluorobenzoyl chloride yields 5.The corresponding 2-γ-(p-fluorobenzoyl)propyl-6-oxo-octahydropyrazinopyridoindole (14) is prepared by the oxidation of 1 with mercuric acetate followed by condensation of the resulting 6-oxo derivative (13) with γ-chloro-p-fluorobutyrophenone. 1-Oxo-2-substituted-pyrazinopyridoindoles (16-18) are prepared by the reaction of ethylene oxide on methyl 1,2,3,4-tetrahydropyridoindole-3-carboxylate followed by condensation of the resulting oxazino derivative (15) with amines.These compounds show tranquillizing, anti-inflammatory and diuretic activities.

Piperazino-anilido compounds

Novel 1,4-disubstituted piperazine compounds and pharmaceutical compositions incorporating such compounds in conjunction with orally, parenterally or rectally administrable pharmaceutically acceptable carriers are disclosed. These compounds have coronary vasodilating properties. Also disclosed are processes for preparing these compounds, and novel intermediate compounds used in such processes.