51793-90-9

Usage

InChI:InChI=1/C11H7NOS/c14-11-12-10-8-4-2-1-3-7(8)5-6-9(10)13-11/h1-6H,(H,12,14)

Upstream product

• 2834-92-6 1-amino-2-naphthol 
• 140-89-6 potassium ethyl xanthogenate 
• 75-15-0 carbon disulfide 
• 842-07-9 Sudan I 
• 1198-27-2 1-aminonaphthalene-2-ol hydrochloride 

Downstream Products

• 72246-09-4 2-(3-nitro-phenyl)-naphtho[1,2-d]oxazole-5-thiosulfonic acid S-naphtho[1,2-d]oxazol-2-yl ester 
• 72234-83-4 2-(2-nitro-phenyl)-naphtho[1,2-d]oxazole-5-thiosulfonic acid S-naphtho[1,2-d]oxazol-2-yl ester 
• 74322-43-3 2-(4-nitro-phenylsulfanyl)-naphtho[1,2-d]oxazole 
• 74322-59-1 2-(2-bromo-benzylsulfanyl)-naphtho[1,2-d]oxazole 
• 74322-45-5 2-(3-chloro-4-nitro-phenylsulfanyl)-naphtho[1,2-d]oxazole 
• 7783-06-4 hydrogen sulfide 
• 2834-92-6 1-amino-2-naphthol 
• 4410-27-9 2-methylsulfanyl-naphtho[1,2-d]oxazole 
• 199293-01-1 2-(4-methyl-1-homopiperazinyl)naphtho[1,2-d]oxazole 
• 74322-62-6 2-(2,4-dinitro-benzenesulfonyl)-naphtho[1,2-d]oxazole 
• 83557-12-4 N-(4-Methoxy-phenyl)-2-(naphtho[1,2-d]oxazol-2-ylsulfanyl)-acetamide 

Relevant academic research and scientific papers

Regioselective thiolation of arenes and heteroarenes: C-H functionalization strategy for C-S bond formation

A facile transition-metal-free oxidative cross-dehydrogenative coupling reaction involving selective formation of a C-S bond leading to the synthesis of arylthiobenzoxazoles, heteroarylthiobenzoxazoles, and arylthiobenzothiazoles has been described. This highly regioselective C-H functionalization reaction with electron-rich aromatic systems including heteroaromatics is achieved by reversing the reactivity of sulfur in the presence of a suitable oxidant and strong acid. (Chemical Equation Presented).

Synthesis and use of achiral oxazolidine-2-thiones in selective preparation of trans 2,5-disubstituted tetrahydrofurans

The use of achiral N-acetyloxazolidine-2-thiones in the C-glycosylation of lactol acetates has allowed us to prepare with high diastereoselectivity the expected trans 2,5-disubstituted tetrahydrofurans. A study based on the role of the steric hindrance of the N-acetyloxazolidine-2-thiones is reported. Wiley-VCH Verlag GmbH & Co. KGaA, 2009.

Pharmaceutical compositions for CNS and other disorders

The present invention relates to a method of treating disorders of the Central Nervous System (CNS) and other disorders in a mammal, including a human, by administering to the mammal a CNS-penetrant α7 nicotinic receptor agonist. It also relates to pharmaceutical compositions containing a pharmaceutically acceptable carrier and a CNS-penetrant α7 nicotinic receptor agonist.

Pharmaceutical composition for the treatment of CNS and other disorders

The present invention relates to a method of treating disorders of the Central Nervous System (CNS) and other disorders in a mammal, including a human, by administering to the mammal a CNS-penetrant α7 nicotinic receptor agonist. It also relates to pharma

Serotonin 5-HT3 receptor partial activator

This invention provides a serotonin 5-HT3 receptor partial activator which has a serotonin 5-HT3 receptor activating action, in addition to its serotonin 5-HT3 receptor antagonism, and does not cause constipation as a side effect. Particularly, based on the finding that newly synthesized benzoxazole derivatives typified by the compounds of the following formula (2) have strong serotonin 5-HT3 receptor antagonism and serotonin 5-HT3 receptor activating action, this invention provides these benzoxazole derivatives as serotonin 5-HT3 receptor partial activators. In the above formula, R1 to R4 may be the same or different from one another and each represents a hydrogen atom, a halogen atom, a substituted or unsubstituted lower alkyl group, a substituted or unsubstituted lower alkenyl group or a substituted or unsubstituted amino group, or two groups of R1 and R2 may be linked together to form a ring structure, namely benzene ring; R5 represents a hydrogen atom, a substituted or unsubstituted lower alkyl group or a substituted or unsubstituted lower alkenyl group; and m is an integer of 1 to 4.

3-[1-(2-Benzoxazolyl)hydrazino]propanenitrile derivatives: Inhibitors of immune complex induced inflammation

3-[1-(2-Benzoxazolyl)hydrazino]propanenitrile derivatives were evaluated in the dermal and pleural reverse passive Arthus reactions in the rat. In the pleural test these compounds were effective in reducing exudate volume and accumulation of white blood cells. This pattern of activity was similar to that of hydrocortisone and different from that of indomethacin. The structural requirements for inhibiting the Arthus reactions were studied by systematic chemical modification of 1. These structure-activity relationship studies revealed that nitrogen 1' of the hydrazino group is essential for activity and must be electron rich, whereas chemical modifications of other sites of 1 had only a modest effect on activity.