51796-64-6Relevant academic research and scientific papers
3-ARYL PROPIOLONITRILE COMPOUNDS FOR THIOL LABELING
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Paragraph 0172-0173; 0209, (2016/06/13)
The present invention relates to a process for labeling compounds comprising thiol moieties with 3-arylpropiolonitrile compounds, to 3-arylpropiolonitrile compounds substituted with tag moieties and to specific 3-arylpropiolonitrile linkers.
3-aryl propiolonitrile compounds for thiol labeling
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Page/Page column, (2015/01/18)
The present invention relates to a process for labeling compounds comprising thiol moieties with 3-arylpropiolonitrile compounds, to 3-arylpropiolonitrile compounds substituted with tag moieties and to specific 3-arylpropiolonitrile linkers.
One-pot synthesis of conjugated alkynenitriles from aldehydes
Kim, Joong-Gon,Lee, Eun Hwa,Jang, Doo Ok
, p. 2299 - 2301 (2007/10/03)
A method of preparing conjugated alkynenitriles was developed from various aldehydes with CCl3CN and PPh3 in the presence of tBuLi. The reaction proceeded via α-chlorovinyl nitrile as an intermediate without any side react
Ring Contraction of 2-Azidoquinoline and Quinoxaline 1-Oxides
Abramovitch, Rudolph A.,Cue, Berkeley W.
, p. 5316 - 5319 (2007/10/02)
Thermal ring contraction of 2-azidoquinoline 1-oxide with loss of nitrogen did not lead to the desired 2-cyano-1-hydroxyindole.Instead, 2-cyanoisatogen (9), 2,2'-dicyano-3,3'-bis (10), and 2-aminoquinoline 1-oxide (7) were formed.The mechanism is believed to involve an intermolecular addition to the intermediate cis-o-nitrosocinnamonitrile formed in a concerted ring-opening nitrogen loss, i.e., not involving a nitrene intermediate.In accord with this, both 2-azido-4-methylquinoline 1-oxide and 2-azidoquinoxaline 1-oxide give the expected 2-cyano-1-hydroxy-3-methylindole (18) and 2-cyano-1-hydroxybenzimidazole (26), respectively.
