80151-24-2

Basic information

• Product Name: 3-(2-NITRO-PHENYL)-PROP-2-YN-1-OL
• Synonyms: 3-(2-NITRO-PHENYL)-PROP-2-YN-1-OL;3-(2-Nitrophenyl)-2-propyn-1-ol
• CAS NO: 80151-24-2
• Molecular Formula: C₉H₇NO₃
• Molecular Weight: 177.16
• Mol File: 80151-24-2.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 340.8 °C at 760 mmHg
• Flash Point: 152.8 °C
• Appearance: /
• Density: 1.34 g/cm³
• Vapor Pressure: 3.24E-05mmHg at 25°C
• Refractive Index: 1.616
• CAS DataBase Reference: 3-(2-NITRO-PHENYL)-PROP-2-YN-1-OL(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(2-NITRO-PHENYL)-PROP-2-YN-1-OL(80151-24-2)
• EPA Substance Registry System: 3-(2-NITRO-PHENYL)-PROP-2-YN-1-OL(80151-24-2)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 80151-24-2(Hazardous Substances Data)

Usage

General Description

3-(2-NITRO-PHENYL)-PROP-2-YN-1-OL, also known as 2-Nitro-3-phenylprop-2-yn-1-ol, is a chemical compound with the molecular formula C9H7NO3. It is a yellow solid that is soluble in organic solvents such as ethanol and acetone. 3-(2-NITRO-PHENYL)-PROP-2-YN-1-OL has an alkynyl group and a nitrophenyl group, making it useful in organic synthesis and as a building block in the production of pharmaceuticals and agrochemicals. It may also have potential applications in materials science and as a chemical intermediate in the production of various other organic compounds. 3-(2-NITRO-PHENYL)-PROP-2-YN-1-OL should be handled with care as it is considered to be a hazardous chemical with potential health and environmental risks.

InChI:InChI=1/C9H7NO3/c11-7-3-5-8-4-1-2-6-9(8)10(12)13/h1-2,4,6,11H,7H2

Upstream product

• 577-19-5 2-nitrophenyl bromide 
• 107-19-7 propargyl alcohol 
• 609-73-4 o-nitroiodobenzene 

Downstream Products

• 665033-45-4 2-(3-tert-butyldimethylsilyloxy-1-propynyl)-nitrobenzene 
• 664981-88-8 N-{2-[3-(tert-butyl-dimethyl-silanyloxy)-prop-1-ynyl]-phenyl}-4-methyl-benzenesulfonamide 
• 665033-47-6 2-(3-tert-butyldimethylsilyloxy-1-propynyl)aniline 
• 665033-49-8 N-[2-(3-hydroxy-prop-1-ynyl)-phenyl]-4-methyl-benzenesulfonamide 
• 1268381-71-0 (3-(2-nitrophenyl)prop-2-ynyl)(3-p-tolylprop-2-ynyl)sulfane 
• 1268381-66-3 1-nitro-2-(3-(3-p-tolylprop-2-ynylsulfonyl)prop-1-ynyl)benzene 
• 1268381-74-3 C₁₁H₉NO₃S 
• 51796-64-6 3-(2-nitrophenyl)propiolonitrile 
• 1287769-23-6 4-iodo-3-(2-nitrophenyl)isoxazole 
• 1287769-10-1 benzyl 2,5-dihydro-4-iodo-3-(2-nitrophenyl)-2H-isoxazole-2-carboxylate 
• 1287768-90-4 isopropyl (3-(2-nitrophenyl)-2-propynyl)oxycarbamate 
• 1287768-73-3 benzyl (3-(2-nitrophenyl)-2-propynyl)oxycarbamate 
• 1287768-72-2 O-(3-(2-nitrophenyl)-2-propynyl)hydroxylamine 
• 1185743-31-0 3-bromo-1-(2-nitrophenyl)-1-propyne 

Relevant articles and documents

Selectivity in Garratt-Braverman cyclization: An experimental and computational study

Bispropargyl sulfones equipped with aromatic rings of dissimilar nature were synthesized. Under basic conditions, these sulfones isomerized to the bisallenic sulfones, creating a competitive scenario between two alternate Garratt-Braverman (GB) cyclizatio

Et2Zn-catalyzed intramolecular hydroamination of alkynyl sulfonamides and the related tandem cyclization/addition reaction

(Chemical Equation Presented) Intramolecular hydroamination of alkynyl amides was effected by a catalytic amount of Et2Zn (20 mol %) to form indole derivatives, and a tandem cyclization/nucleophilic addition procedure involving reaction of the indole zinc salt intermediate with acid chlorides or halides was developed to provide an efficient approach to C3-substituted indole derivatives when an excess of Et2Zn (120 mol %) was used.

Development of an Efficient Procedure for Indole Ring Synthesis from 2-Ethynylaniline Derivatives Catalyzed by Cu(II) Salts and Its Application to Natural Product Synthesis

The development of efficient methods for the indole synthesis catalyzed by Cu(II) salts and its applications were investigated. Cu(OAc)2 has been proved to be the best catalyst for the synthesis of various 1-p-tolylsulfonyl or 1-methylsulfonylindoles, which have both electron-withdrawing and electron-donating groups on the aromatic ring and C2 position of indoles. For the primary aniline derivatives, Cu(OCOCF 3)2 showed good activities, while Cu(OAc)2 was a good catalyst for the cyclization of secondary anilines. This methodology could be applied to the sequential cyclization reaction for the compounds which have the electrophilic part in the same molecule. By prior treatment with KH, the sequential cyclization was realized to provide the tricyclic ring systems, but it was limited to five- and six-membered rings for the second cyclization. Finally, formal and total synthesis of hippadine with the Cu(II)-promoted indole synthesis as the key step was accomplished.