80151-24-2

Usage

Uses

Used in Organic Synthesis:
3-(2-NITRO-PHENYL)-PROP-2-YN-1-OL is used as a building block in organic synthesis for its unique structural features, including the alkynyl and nitrophenyl groups, which facilitate the creation of a variety of complex organic molecules.
Used in Pharmaceutical Production:
In the pharmaceutical industry, 3-(2-NITRO-PHENYL)-PROP-2-YN-1-OL is utilized as a key intermediate in the synthesis of various drugs, leveraging its chemical properties to contribute to the development of new medicinal compounds.
Used in Agrochemical Production:
3-(2-NITRO-PHENYL)-PROP-2-YN-1-OL serves as a chemical intermediate in the agrochemical sector, playing a role in the synthesis of pesticides and other agricultural chemicals to enhance crop protection and yield.
Used in Materials Science:
3-(2-NITRO-PHENYL)-PROP-2-YN-1-OL is also used in materials science for the development of new materials, potentially due to its ability to form unique molecular structures that could have applications in various material technologies.
Used as a Chemical Intermediate:
3-(2-NITRO-PHENYL)-PROP-2-YN-1-OL is used as a chemical intermediate in the production of a range of other organic compounds, highlighting its versatility in chemical reactions and its importance in the synthesis of diverse chemical products.

InChI:InChI=1/C9H7NO3/c11-7-3-5-8-4-1-2-6-9(8)10(12)13/h1-2,4,6,11H,7H2

Upstream product

• 609-73-4 o-nitroiodobenzene 
• 107-19-7 propargyl alcohol 
• 577-19-5 2-nitrophenyl bromide 

Downstream Products

• 16433-96-8 2-ethynyl-1-nitrobenzene 
• 665033-45-4 2-(3-tert-butyldimethylsilyloxy-1-propynyl)-nitrobenzene 
• 1185743-31-0 3-bromo-1-(2-nitrophenyl)-1-propyne 
• 1268381-71-0 (3-(2-nitrophenyl)prop-2-ynyl)(3-p-tolylprop-2-ynyl)sulfane 
• 1268381-66-3 1-nitro-2-(3-(3-p-tolylprop-2-ynylsulfonyl)prop-1-ynyl)benzene 
• 1268381-74-3 C₁₁H₉NO₃S 
• 51796-64-6 3-(2-nitrophenyl)propiolonitrile 
• 1287769-23-6 4-iodo-3-(2-nitrophenyl)isoxazole 
• 1287769-10-1 benzyl 2,5-dihydro-4-iodo-3-(2-nitrophenyl)-2H-isoxazole-2-carboxylate 
• 1287768-90-4 isopropyl (3-(2-nitrophenyl)-2-propynyl)oxycarbamate 
• 1287768-73-3 benzyl (3-(2-nitrophenyl)-2-propynyl)oxycarbamate 
• 1287768-72-2 O-(3-(2-nitrophenyl)-2-propynyl)hydroxylamine 
• 138956-08-8 Ethyl 3-<amino>glyoxylyl>indole-2-acetate 
• 138956-07-7 <(2'-Nitrophenyl)propargyl>amine 

Relevant academic research and scientific papers

Selectivity in Garratt-Braverman cyclization: An experimental and computational study

Bispropargyl sulfones equipped with aromatic rings of dissimilar nature were synthesized. Under basic conditions, these sulfones isomerized to the bisallenic sulfones, creating a competitive scenario between two alternate Garratt-Braverman (GB) cyclizatio

Synthesis of a new mutagenic benzoazepinoquinolinone derivative

A novel mutagenic compound 1, isolated as a Maillard product from tryptophan and glucose, was synthesized using Larock's quinoline formation, where addition of iodonium cation to an acetylene moiety of N-propargylaniline triggers subsequent intramolecular

Et2Zn-catalyzed intramolecular hydroamination of alkynyl sulfonamides and the related tandem cyclization/addition reaction

(Chemical Equation Presented) Intramolecular hydroamination of alkynyl amides was effected by a catalytic amount of Et2Zn (20 mol %) to form indole derivatives, and a tandem cyclization/nucleophilic addition procedure involving reaction of the indole zinc salt intermediate with acid chlorides or halides was developed to provide an efficient approach to C3-substituted indole derivatives when an excess of Et2Zn (120 mol %) was used.

Use of functionalized onium salts as a soluble support for organic synthesis

The invention relates to the use of a onium salt functionalized by at least one organic function, as a soluble support, in the presence of at least one organic solvent, for organic synthesis of a molecule, in a homogenous phase, by at least one transformation of said organic function. The onium salt enables the synthesized molecule to be released. The onium salt is present in liquid or solid form at room temperature and corresponds to formula A1+, X1?, wherein A1+ represents a cation and X1? represents an anion.

Development of an Efficient Procedure for Indole Ring Synthesis from 2-Ethynylaniline Derivatives Catalyzed by Cu(II) Salts and Its Application to Natural Product Synthesis

The development of efficient methods for the indole synthesis catalyzed by Cu(II) salts and its applications were investigated. Cu(OAc)2 has been proved to be the best catalyst for the synthesis of various 1-p-tolylsulfonyl or 1-methylsulfonylindoles, which have both electron-withdrawing and electron-donating groups on the aromatic ring and C2 position of indoles. For the primary aniline derivatives, Cu(OCOCF 3)2 showed good activities, while Cu(OAc)2 was a good catalyst for the cyclization of secondary anilines. This methodology could be applied to the sequential cyclization reaction for the compounds which have the electrophilic part in the same molecule. By prior treatment with KH, the sequential cyclization was realized to provide the tricyclic ring systems, but it was limited to five- and six-membered rings for the second cyclization. Finally, formal and total synthesis of hippadine with the Cu(II)-promoted indole synthesis as the key step was accomplished.

Synthesis of the Staurosporine Aglycon

A short synthesis of the staurosporine aglycon (6) is reported, the indolocarbazole skeleton being constructed by an intramolecular Diels-Alder reaction followed by a nitrene-mediated ring closure.The synthesis starts by acylation of ethyl indole-2-acetat