518058-79-2Relevant articles and documents
Synthesis and bioevaluation of 2-phenyl-5-methyl-2H-1,2,3-triazole-4-carboxylic acid/carbohydrazide derivatives as potent xanthine oxidase inhibitors
Shi, Ailong,Wang, Defa,Wang, He,Wu, Yue,Tian, Haiqiu,Guan, Qi,Bao, Kai,Zhang, Weige
, p. 114879 - 114888 (2016/12/24)
A series of 2-phenyl-5-methyl-2H-1,2,3-triazole-4-carboxylic acids/carbohydrazides as analogues of febuxostat were synthesized and evaluated for their in vitro xanthine oxidase (XO) inhibitory activity. Among these compounds, the carboxylic acid derivatives 7a-h and 8a-h exhibited high potency in the submicromolar/nanomolar range. Steady-state kinetics experiment revealed that 7f was a mixed-type inhibitor of xanthine oxidase. In addition, a molecular docking study of 7f was performed to determine its binding mode at the active site of xanthine oxidase.
Bicyclic compositions and methods for modulating a kinase cascade
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Page/Page column 75, (2008/06/13)
The invention relates to compounds and methods for modulating one or more components of a kinase cascade.