518291-07-1

Basic information

• Product Name: 1-{5-isopropyl-2-methyl-4-[2-hydroxy-3-(pyrrolidin-1-yl)propoxy}phenyl]ethan-1-one
• CAS NO: 518291-07-1
• Molecular Weight: 319.444
• Mol File: 518291-07-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-{5-isopropyl-2-methyl-4-[2-hydroxy-3-(pyrrolidin-1-yl)propoxy}phenyl]ethan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-{5-isopropyl-2-methyl-4-[2-hydroxy-3-(pyrrolidin-1-yl)propoxy}phenyl]ethan-1-one(518291-07-1)
• EPA Substance Registry System: 1-{5-isopropyl-2-methyl-4-[2-hydroxy-3-(pyrrolidin-1-yl)propoxy}phenyl]ethan-1-one(518291-07-1)

Safety Data

• Hazardous Substances Data: 518291-07-1(Hazardous Substances Data)

Upstream product

• 37847-35-1 4-acetyl-2-isopropyl-5-methylphenol 
• 123-75-1 pyrrolidine 
• 850165-30-9 3-(4-acetyl-2-isopropyl-5-methylphenoxy)-1,2-epoxypropane 

Relevant articles and documents

Substituted acrylophenones and related mannich bases as possible spermicides and inhibitors of HIV envelope glycoprotein-CD4 interaction.

Several appropriately substituted 4-(dialkylamino-alkyl)-substituted-styryl-alkyl ketones or acetophenones were prepared and subjected to the Mannich reaction to yield compounds that would incorporate both alpha,beta-unsaturated keto groups and a substituted aminomethyl function with or without another olefinic moiety at position 4. The spermicidal activity of the prepared compounds was evaluated. Several compounds 2d, 4a and 4e were found to possess spermicidal activity at 0.005% concentration, while compounds 2a, 2c, 2f, 3a and 4b were active at 0.01% concentration. Compounds 2a, 2c, 3a, 4a and 4e also inhibited the interaction between recombinant HIV Env and CD4. Out of these, compound 2c was found to be most active.