5183-27-7Relevant articles and documents
PHOSPHORUS-CONTAINING AMINOCARBOXYLIC ACIDS. 1. METHOD OF PREPARATION OF PHOSPHONATE-TYPE COMPOUNDS
Ragulin, V. V.,Bofanova, M. E.,Tsvetkov, E. N.
, p. 2377 - 2382 (1989)
A method is described for the synthesis of phosphorus-containing amino carboxylic acids, by the Michaelis-Bekker or Arbuzov phosphorylation of ω-haloalkylacetamidomalonic ester.The latter were obtained by alkylating the sodium salt of acetamidomalonic ester with an excess of the α,ω-dihaloalkane.Acid hydrolysis of the phosphorus-containing alkylacetamidomalonic esters gave the required compounds.