518357-40-9

Usage

Uses

Used in Pharmaceutical Industry:
C-(4'-FLUORO-BIPHENYL-4-YL)-METHYLAMINE HYDROCHLORIDE is used as a key intermediate in the synthesis of various pharmaceutical compounds for the development of new drugs. Its unique structure, including the fluorinated biphenyl and methylamine components, contributes to the creation of medications designed to treat a range of medical conditions.
It is essential to handle and utilize this chemical with caution, adhering to proper safety protocols and regulations to ensure its safe and effective application in pharmaceutical research and development. This careful approach helps maintain the integrity of the drug development process and the safety of those involved in its production and use.

Upstream product

• 3959-07-7 4-Bromobenzylamine 
• 1765-93-1 4-fluoroboronic acid 
• 776291-03-3 (4'-fluoro-[1,1'-biphenyl]-4-yl)methanamine 

Downstream Products

• 776291-03-3 (4'-fluoro-[1,1'-biphenyl]-4-yl)methanamine 

Relevant academic research and scientific papers

Substituted N -(biphenyl-4′-yl)methyl (R)-2-acetamido-3- methoxypropionamides: Potent anticonvulsants that affect frequency (Use) dependence and slow inactivation of sodium channels

We prepared 13 derivatives of N-(biphenyl-4′-yl)methyl (R)-2-acetamido-3-methoxypropionamide that differed in type and placement of a R-substituent in the terminal aryl unit. We demonstrated that the R-substituent impacted the compound's whole animal and cellular pharmacological activities. In rodents, select compounds exhibited excellent anticonvulsant activities and protective indices (PI = TD50/ED50) that compared favorably with clinical antiseizure drugs. Compounds with a polar, aprotic R-substituent potently promoted Na+ channel slow inactivation and displayed frequency (use) inhibition of Na+ currents at low micromolar concentrations. The possible advantage of affecting these two pathways to decrease neurological hyperexcitability is discussed.

(Biphenyl-4-yl)methylammonium chlorides: Potent anticonvulsants that modulate Na+ currents

We have reported that compounds containing a biaryl linked unit (Ar-X-Ar′) modulated Na+ currents by promoting slow inactivation and fast inactivation processes and by inducing frequency (use)-dependent inhibition of Na+ currents. These electrophysiological properties have been associated with the mode of action of several antiepileptic drugs. In this study, we demonstrate that the readily accessible (biphenyl-4-yl)methylammonium chlorides (compound class B) exhibited a broad range of anticonvulsant activities in animal models, and in the maximal electroshock seizure test the activity of (3′-trifluoromethoxybiphenyl-4- yl)methylammonium chloride (8) exceeded that of phenobarbital and phenytoin upon oral administration to rats. Electrophysiological studies of 8 using mouse catecholamine A-differentiated cells and rat embryonic cortical neurons confirmed that 8 promoted slow and fast inactivation in both cell types but did not affect the frequency (use)-dependent block of Na+ currents.