51837-74-2Relevant academic research and scientific papers
A VERSATILE SYNTHESIS OF HYDROXY-9,10-ANTHRAQUINONE-2-CARBOXYLIC ACIDS
Smith, Colin W.,Ambler, Samantha J.,Steggles, David J.
, p. 7447 - 7450 (2007/10/02)
Islandicin, a mould metabolite, can be synthesised in a few, robust, high yielding steps.This procedure can be further elaborated to give a variety of hydroxy-9,10-anthraquinone-2-carboxylic acids.
A New Synthesis of Anthraquinones Using Dihydro-oxazoles and Grignard Reagents Derived from Mg(Anthracene)(THF)3
Nicoletti, Teresa M.,Raston, Colin L.,Sargent, Melvyn V.
, p. 133 - 138 (2007/10/02)
A general synthesis of anthraquinones which depends on the displacement of the methoxy group from an o-methoxyaryldihydro-oxazole by a methoxy substituted benzylmagnesium chloride, generated by using a magnesium-anthracene complex, has been developed.The masked benzylbenzoic acids which result from these reactions are deprotected and then ring-closed to anthrones which on oxidation yield anthraquinones.In this way, the followeing naturally occurring anthraquinones (or derivatives thereof have been synthesized): chrysophanol (9), islandicin (19), digitopurpone (21), tri-O-methylemodin (26), and di-O-methylsoranjidiol (29).
A New Synthesis of Anthraquinones
Nicoletti, Teresa M.,Raston, Colin L.,Sargent, Melvyn V.
, p. 1491 - 1493 (2007/10/02)
Methoxy substituted benzyl magnesium chlorides formed by the use of a magnesium anthracene complex smoothly displace the ortho-methoxy group from (o-methoxyaryl)dihydro-oxazoles (oxazolines); the resultant masked o-benzylbenzoic acids are easily converted into anthraquinones.
