5184-66-7

Basic information

• Product Name: 1-ethyl-4-[(4-methylphenyl)sulfonyl]benzene
• CAS NO: 5184-66-7
• Molecular Formula: C₁₅H₁₆O₂S
• Molecular Weight: 260.3513
• Mol File: 5184-66-7.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 406.9°C at 760 mmHg
• Flash Point: 236.4°C
• Density: 1.147g/cm³
• Vapor Pressure: 1.84E-06mmHg at 25°C
• Refractive Index: 1.567
• CAS DataBase Reference: 1-ethyl-4-[(4-methylphenyl)sulfonyl]benzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-ethyl-4-[(4-methylphenyl)sulfonyl]benzene(5184-66-7)
• EPA Substance Registry System: 1-ethyl-4-[(4-methylphenyl)sulfonyl]benzene(5184-66-7)

Safety Data

• Hazardous Substances Data: 5184-66-7(Hazardous Substances Data)

Usage

Functional groups

Sulfone, Ethyl, Methyl

Structure

Benzene derivative with a sulfone functional group attached to a 4-methylphenyl group and an ethyl group at the 1-position

Applications

Used in the synthesis of pharmaceuticals and agrochemicals

Importance

Potential as a building block for creating more complex molecules

Role

Important intermediate in organic synthesis and drug discovery

Industrial and scientific applications

Wide range of uses in chemical research and development

Physical properties

Unknown, but likely a solid or liquid at room temperature based on molecular size and complexity

Solubility

Unknown, but likely soluble in organic solvents such as ethanol or acetone

Stability

Stable under normal conditions, but may be sensitive to heat, light, or strong acids/bases due to the presence of the sulfone functional group.

Upstream product

• 100-41-4 ethylbenzene 
• 98-59-9 p-toluenesulfonyl chloride 
• 824-79-3 sodium 4-methylbenzenesulfinate 
• 63139-21-9 4-ethylphenylboronic acid 
• 1576-35-8 toluene-4-sulfonic acid hydrazide 

Downstream Products

• 2449-35-6 bis(4-carboxyphenyl)sulfone 

Relevant articles and documents

Sulfonylation of Bismuth Reagents with Sulfinates or SO2through BiIII/BiV Intermediates

Studies to explore the catalytic activities of main-group elements are attractive. We report here our study of sulfonylation of bismuth reagents with sulfinates or SO2 surrogates. Under oxidative conditions, triarylbismuthines and sulfinates were transformed into diaryl sulfones. A transition-metal-like two-electron redox process at the Bi center was achieved in this reaction. Sulfur dioxide generated in situ can also replace sulfinates to deliver the corresponding symmetric diaryl sulfones. A rational mechanism for this reaction was also proposed that involves a Bi(III)-Bi(V) manifold.

A practical and efficient method for the preparation of aromatic sulfones by the reaction of aryl sulfonyl chlorides with arenes catalysed by Fe(OH) 3

Fe (OH)3 catalyses Friedel-Crafts sulfonylation of arenes with aryl sulfonyl chlorides to obtain the corresponding diaryl sulfones in good yields.

An efficient and novel method for the synthesis of aromatic sulfones under solvent - Free conditions

A manipulative simple and rapid reaction of arensulfonyl chloride with aromatic hydrocarbons is described. The reaction is conducted under Friedel-Crafts conditions in the absences of solvent using aluminium chloride as catalysts.