5184-66-7

Usage

Functional groups

Sulfone, Ethyl, Methyl

Structure

Benzene derivative with a sulfone functional group attached to a 4-methylphenyl group and an ethyl group at the 1-position

Applications

Used in the synthesis of pharmaceuticals and agrochemicals

Importance

Potential as a building block for creating more complex molecules

Role

Important intermediate in organic synthesis and drug discovery

Industrial and scientific applications

Wide range of uses in chemical research and development

Physical properties

Unknown, but likely a solid or liquid at room temperature based on molecular size and complexity

Solubility

Unknown, but likely soluble in organic solvents such as ethanol or acetone

Stability

Stable under normal conditions, but may be sensitive to heat, light, or strong acids/bases due to the presence of the sulfone functional group.

Upstream product

• 824-79-3 sodium 4-methylbenzenesulfinate 
• 63139-21-9 4-ethylphenylboronic acid 
• 1576-35-8 toluene-4-sulfonic acid hydrazide 
• 100-41-4 ethylbenzene 
• 98-59-9 p-toluenesulfonyl chloride 

Downstream Products

• 2449-35-6 bis(4-carboxyphenyl)sulfone 

Relevant academic research and scientific papers

Sulfonylation of Bismuth Reagents with Sulfinates or SO2through BiIII/BiV Intermediates

Studies to explore the catalytic activities of main-group elements are attractive. We report here our study of sulfonylation of bismuth reagents with sulfinates or SO2 surrogates. Under oxidative conditions, triarylbismuthines and sulfinates were transformed into diaryl sulfones. A transition-metal-like two-electron redox process at the Bi center was achieved in this reaction. Sulfur dioxide generated in situ can also replace sulfinates to deliver the corresponding symmetric diaryl sulfones. A rational mechanism for this reaction was also proposed that involves a Bi(III)-Bi(V) manifold.

A mild and base-free synthesis of unsymmetrical diaryl sulfones from arylboronic acids and arylsulfonyl hydrazides

A mild and efficient synthesis of diaryl sulfones from arylboronic acids and arylsulfonyl hydrazides is described. Promoted by cupric acetate and in the absence of additional ligand and base, the cross-coupling reaction could afford a series of unsymmetrical diaryl sulfones in moderate to good yields at room temperature under neutral and ambient conditions. Georg Thieme Verlag Stuttgart New York.

A practical and efficient method for the preparation of aromatic sulfones by the reaction of aryl sulfonyl chlorides with arenes catalysed by Fe(OH) 3

Fe (OH)3 catalyses Friedel-Crafts sulfonylation of arenes with aryl sulfonyl chlorides to obtain the corresponding diaryl sulfones in good yields.

An efficient and convenient method for the synthesis of aromatic sulfones catalysed by ZrO2/S2O82- solid superacid

A manipulatively simple and rapid procedure for the synthesis of diaryl sulfones from arylsulfonyl chlorides with aromatic compounds is described; the reaction is conducted under Friedel-Crafts conditions in the absence of solvent using ZrO2/S2O82- as catalyst in 78-93% yields.

An efficient and novel method for the synthesis of aromatic sulfones under solvent - Free conditions

A manipulative simple and rapid reaction of arensulfonyl chloride with aromatic hydrocarbons is described. The reaction is conducted under Friedel-Crafts conditions in the absences of solvent using aluminium chloride as catalysts.

Organic reactions under solid-state conditions

Manipulatively simple and rapid methods are described for the synthesis of: chiral sulfinate esters from sulfonyl chlorides and sufonic acids; aldehydes and ketones from oximes, alcohols, hydrozones; sulfoxides from sulfides; and disulfides from thiols. The chemical yields are good to excellent and diastereoselectivity is high.