51850-60-3

Upstream product

• 68571-74-4 3-methylisoxazolo<5,4-d>pyrimidin-4(5H)-one 
• 35261-01-9 3-methyl-4-cyano-5-aminoisoxazole 
• 68-12-2 N,N-dimethyl-formamide 
• 5417-82-3 (1-ethoxyethylidene)malononitrile 
• 89799-07-5 4-Amino-3-methyl-isoxazolo<5.4-d>pyrimidin 
• 35261-06-4 5-amino-3-methyl-1,2-oxazole-4-carboxamide 

Downstream Products

• 894591-18-5 N-(3,5-dimethoxyphenyl)-3-methylisoxazolo[5,4-d]pyrimidin-4-amine 
• 1023758-05-5 N-(4-methoxyphenyl)-N,3-dimethylisoxazolo[5,4-d]pyrimidin-4-amine 
• 175348-28-4 3-methyl-4-propylaminoisoxazolo<5,4-d>pyrimidine 

Relevant academic research and scientific papers

Pyrimidine ring-containing substituted five-membered heterocyclic compound as well as preparation method and application thereof

The invention discloses a substituted five-membered heterocyclic compound containing pyrimidine rings. The structure is shown in a formula I: (the formula I is shown in the description), and the definition of each substation group is shown in the descript

Pyrimidine-containing fused heterocyclic compounds, and preparation method and application thereof

The invention discloses pyrimidine-containing fused heterocyclic compounds, and a preparation method and application thereof. The structures of the pyrimidine-containing fused heterocyclic compounds are as shown in a general formula I which is described in the specification. In the general formula I, each substituent group is as defined in the specification. The compounds provided by the inventionhave broad-spectrum bactericidal activity, and have excellent prevention and treatment effects on cucumber downy mildew, wheat powdery mildew and the like.

Substituted six-membered heterocyclic compound containing pyrimidine rings and preparation method and application thereof

The invention discloses a substituted six-membered heterocyclic compound containing pyrimidine rings. The structure is shown in a formula I: (the formula I is shown in the description), and the definition of each substation group is shown in the description. The substituted six-membered heterocyclic compound has the advantages that the broad-spectrum bacteria-killing and insect-killing activity isrealized; the good preventing and controlling effect is realized for cucumber downy mildew, wheat powdery mildew, puccinia polysora, rice blast, cucumber anthracnose and the like; meanwhile, the goodinsect-killing activity is realized.

N-ARYL-ISOXAZOLOPYRIMIDIN-4-AMINES AND RELATED COMPOUNDS AS ACTIVATORS OF CASPASES AND INDUCERS OF APOPTOSIS AND THE USE THEREOF

Disclosed are N-aryl-isoxazolopyrimidin-4-amines and related compounds thereof, represented by the Formula (I): wherein Ar, R1-R5, A, B, D, E, F and H are defined herein. The present invention relates to the discovery that compounds having Formula I are activators of caspases and inducers of apoptosis. Therefore, the activators of caspases and inducers of apoptosis of this invention may be used to induce cell death in a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.

Regioselective synthesis of substituted isoxazolo[5,4-d]pyrimidines

A convenient regioselective synthesis of new N- and O-substituted isoxazolo[5,4-d]pyrimidine derivatives is described.

Synthesis of fused pyrimidinones by reaction of aminoarene-carboxamide with esters; Preparation of pyrrolo[2,3-d]-, thieno[2,3-d]-, isoxazolo[5,4-d]- and 1,2,3-triazolo[4,5-d]pyrimidinones, and quinazolones

Several fused pyrimidinones were synthesized by reaction of aminoarenecarboxamide with esters in moderate to good yields. In the presence of sodium ethoxide, treatments of 2-amino-l-phenyl-3-pyrrolecarboxamide(4, 5, and 6), 2-amino-3-thiophenecarboxamide (14), 3-amino-4-isoxazolecarboxamide (10 and 11), 4-amino-1,2,3-triazole-5-carboxamide (16), and o-aminobenzamide (18) with esters (3) such as ethyl formate (3a) and ethyl acetate (3b) led to the corresponding pyrrolo[2,3-d]- (7, 8, and 9), and thieno[2,3-d]pyrimidin-4(3H)-ones (15), isoxazolo[5,4-d]pyrimidin-4(5H)-ones (12 and 13), 1,2,3-triazolo[4,5-d]pyrimidin-7(6H)-ones (17), and 4(3H)-quinazolones (19), respectively.