51866-92-3

Upstream product

• 657-26-1 L-lysine dihydrochloride 
• 98-59-9 p-toluenesulfonyl chloride 
• 657-27-2 L-Lysine hydrochloride 

Downstream Products

• 134785-40-3 (S)-ethyl 1,6,11,16-tetratosyl-1,6,11,16-tetraazacycloheneicosan-17-carboxylate 
• 134785-39-0 (S)-ethyl 1,6,11-tritosyl-1,6,11-triazacyclohexadecane-12-carboxylate 
• 134785-37-8 ethyl 2,6-bis(tosylamino)hexanoate 

Relevant academic research and scientific papers

Amino acid derivatives as HIV aspartyl protease inhibitors

The present invention relates to a class of amino acid derivatives with HIV aspartyl protease inhibitory properties.

Macrocyclic Polyamines -N3 and -N4: Synthesis and Study of their ATP Complexation by 31P Nuclear Magnetic Resonance Spectroscopy

The macrocyclic polyamines -N3, compound 1, and -N4, compound 2, possessing a hydroxymethyl side-chain have been synthesized.The macrocyclisation was achieved by condensation of lysine ditosate 3b with appropriate components 5 and 6 in the presence of CsCO3 to obtain 7 and 8 in 33 and 37percent yield, respectively.The complexation of polyamines 1 and 2 with ATP was studied by 31P NMR spectroscopy, which indicated a specific recognition of γ-phosphorus of ATP (NMe4 salt) by the polyamines.The binding constant estimates indicated that ATP binds compound 2 ca. 35-times stronger than it does compound 1.The binding curves indicated a definite 1:1 stoicheiometry for 2:ATP complex, and not so well defined stoicheiometry for 1:ATP binding.The mononucleotides, AMP and cAMP, and dinucleotide TpT did not show significant complexation with either compound 1 or 2.The binding of ATP by macrocyclic polyamines 1 and 2 and the presence of a hydroxymethyl side-chain to link with a nucleophile may aid rational design of chemical nucleases.