51871-42-2

Basic information

• Product Name: BOC-GLY-LEU-OH
• Synonyms: BOC-L-GLYCYL LEUCINE;BOC-GLY-LEU-OH;(S)-2-(2-(tert-butoxycarbonylamino)acetamido)-4-methylpentanoic acid;REF DUPL: Boc-Gly-Leu-OH;N-Boc-glycyl-L-leucine, 98%;N-[(1,1-Dimethylethoxy)carbonyl]glycyl-L-leucine;Boc-Gly-L-Leu-OH;(Tert-Butoxy)Carbonyl Gly-Leu-OH
• CAS NO: 51871-42-2
• Molecular Formula: C₁₃H₂₄N₂O₅
• Molecular Weight: 288.34
• EINECS: 1533716-785-6
• Mol File: 51871-42-2.mol
• Article Data: 9

Chemical Properties

• Appearance: /Solid
• Storage Temp.: 2-8°C
• CAS DataBase Reference: BOC-GLY-LEU-OH(CAS DataBase Reference)
• NIST Chemistry Reference: BOC-GLY-LEU-OH(51871-42-2)
• EPA Substance Registry System: BOC-GLY-LEU-OH(51871-42-2)

Safety Data

• Hazardous Substances Data: 51871-42-2(Hazardous Substances Data)

Usage

General Description

BOC-GLY-LEU-OH is a chemical compound belonging to the family of peptide building blocks utilized commonly in biochemical molecular research. The "BOC" in its name refers to a protective group known as t-BOC or tert-butoxycarbonyl, which prevents undesired reactions during the synthesis process. "GLY" stands for the amino acid glycine and "LEU" for the amino acid leucine. The “OH” at the end represents a Hydroxyl group which is a molecule consisting of one oxygen atom and one hydrogen atom. Overall, BOC-GLY-LEU-OH is an advanced raw material used in the synthesis and composition of various biochemical compounds.

Upstream product

• 869-19-2 Glycyl-L-leucine 
• 24424-99-5 di-tert-butyl dicarbonate 
• 61-90-5 L-leucine 
• 67084-40-6 1-(N-tert-butoxycarbonyl-glycyloxy)-1H-benzotriazole 
• 3392-07-2 tert-butyl N-{2-[(2,5-dioxopyrrolidin-1-yl)oxy]-2-oxoethyl}carbamate 
• 2666-93-5 (S)-Leu-OMe 
• 4530-20-5 BOC-glycine 
• 17790-86-2 tert-butyl 2-oxo-2-(2-phenylhydrazinyl)ethylcarbamate 
• 77162-21-1 Boc-Gly-Leu-NHNHPh 
• 202265-96-1 N-tert-butyloxycarbonyl-L-glycyl-L-leucine 2-methoxyethyl ester 
• 7535-69-5 (S)-methyl 2-(2-((tert-butoxycarbonyl)amino)acetamido)-4-methylpentanoate 

Downstream Products

• 1340584-80-6 Boc-Gly-L-Leu-L-Cys(S-Cbz-L-Ala)-Gly-OCH₃ 
• 1340584-81-7 H-Gly-L-Leu-L-Cys(S-Cbz-L-Ala)-Gly-OCH₃ hydrochloride 
• 1340584-83-9 C₃₆H₄₈N₆O₁₁S 
• 1340585-01-4 C₅₀H₇₂N₁₀O₁₆S₂ 
• 108456-25-3 methyl (2S,5S)-2-benzyl-8-[(tert-butoxycarbonyl)amino]-5-isobutyl-4,7-dioxo-3,6-diazaoctanoate 
• 118700-52-0 Boc-Gly-Leu-Gly-OBzl 
• 76487-60-0 Z-Aib-Pro-Aib-Ala-Aib-Ala-Gln-Aib-Val-Aib-Gly-Leu-Aib-OMe 
• 76487-61-1 Z-Aib-Pro-Aib-Ala-Aib-Ala-Gln-Aib-Val-Aib-Gly-Leu-Aib-OH 
• 474317-02-7 Boc-Gly-Leu-Met-Gly-Met-Gly-NHNHPh 

Relevant articles and documents

Stereoretentive Reactions at the Anomeric Position: Synthesis of Selenoglycosides

Reported is the stereospecific cross-coupling of anomeric stannanes with symmetrical diselenides, resulting in the synthesis of selenoglycosides with exclusive anomeric control. The reaction proceeds without the need for directing groups and is compatible

Microwave-assisted chemical ligation of S-acyl peptides containing non-terminal cysteine residues

An efficient approach for the synthesis of a series of S-acyl peptides containing internal cysteine residues has been developed and the chemical long-range ligation of these S-acyl peptides via 5-, 8-, 11- and 14-membered cyclic transition states has been

Phenylhydrazide as an enzyme-labile protecting group in peptide synthesis

The enzymatic cleavage of amino acid phenylhydrazides with the enzyme tyrosinase (EC 1.14.18.1) offers a new, mild, and selective method for C-terminal deprotection of peptides. The advantages of the described methodology are the very mild oxidative removal of the protecting group at room temperature and pH 7, a high chemo- and regioselectivity, and the availability of the biocatalyst. Even in oxygen-saturated solution, the oxidation of sensitive methionine residues was not observed. These features make the methodology suitable for the synthesis of sensitive peptide conjugates. Mechanistic data suggest that the hydrolysis of the oxidized adducts proceeds by a free-radical mechanism.