5189-96-8 Usage
Uses
Used in Pharmaceutical Research:
10β-hydroxyestr-4-ene-3,17-dione is used as a research compound for studying the mechanisms of estrogen biosynthesis and its regulation. Understanding the role of this steroid in the body can help researchers develop new therapeutic strategies for conditions related to hormonal imbalances.
Used in Competitive Aromatase Inhibition Studies:
In the field of endocrinology, 10β-hydroxyestr-4-ene-3,17-dione is employed as a competitive inhibitor in aromatase inhibition studies. Aromatase is an enzyme responsible for the conversion of androgens to estrogens. By inhibiting this enzyme, researchers can investigate the effects of reduced estrogen levels on various physiological processes and develop potential treatments for conditions such as breast cancer, which is often hormone-dependent.
Used in Drug Development:
10β-hydroxyestr-4-ene-3,17-dione may also be used as a starting material or intermediate in the synthesis of other steroidal compounds with potential pharmaceutical applications. Its unique structure can be modified to create new molecules with specific biological activities, which could be useful in the development of novel drugs for various medical conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 5189-96-8 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 5,1,8 and 9 respectively; the second part has 2 digits, 9 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 5189-96:
(6*5)+(5*1)+(4*8)+(3*9)+(2*9)+(1*6)=118
118 % 10 = 8
So 5189-96-8 is a valid CAS Registry Number.
InChI:InChI=1/C18H24O3/c1-17-8-7-15-13(14(17)4-5-16(17)20)3-2-11-10-12(19)6-9-18(11,15)21/h10,13-15,21H,2-9H2,1H3/t13?,14?,15?,17-,18+/m0/s1
5189-96-8Relevant academic research and scientific papers
Budesinsky, Milos,Fajkos, Jan,Guenter, Jaroslav,Kasal, Alexander
, p. 507 - 518 (2005)
On epoxidation of estr-5(10)-ene-3,17-dione, the 5β,10β-epoxide is the major product. The mixture of epoxides was converted into 5,10β-dihydroxy-5α-estrane-3,17-dione, 10α- and 10β-hydroxyestr-4-ene-3,17-dione, and estrone. Due to the sensitivity of the products, 1H NMR was the best way to monitor the reaction pathway.
Biosynthesis of Estrogens bz Microsomal Placental Aromatase; Isolation and Metabolism of 10β-Hydroxyestr-4-ene-3,17-dione
Caspi, Eliahu,Dharmaratne, H. Ranjith W.,Shackleton, Cedric
, p. 1699 - 1700 (2007/10/02)
Incubation of -19-oxoandrost-4-ene-3,17-dione (2a) with microsomal aromatase gave inter alia -10β-hydroxyestr-4-ene-3,17-dione (1), whose analogue (1b) on incubation with the aromatase gave 10β,17β-dihydroxyestr-4-en-3-one (1d) (ca. 10percent) and no estrogens which would indicate that (1b) is not an obligatory estrogen precursor.
