881-50-5

Usage

Uses

Used in Pharmaceutical Synthesis:
4'-BROMO-2'-NITROACETANILIDE is used as a building block for the synthesis of various pharmaceuticals, contributing to the development of new drugs and therapeutic agents. Its unique chemical structure allows for the creation of a wide range of heterocyclic compounds with potential medicinal properties.
Used in Organic Compound Synthesis:
In the field of organic chemistry, 4'-BROMO-2'-NITROACETANILIDE is employed as a key intermediate for the synthesis of various organic compounds. Its reactivity and functional groups enable the formation of diverse chemical structures, expanding the scope of organic synthesis.
Used in Dye and Pigment Production:
4'-BROMO-2'-NITROACETANILIDE is utilized as a precursor in the production of dyes and pigments. Its chemical properties allow for the development of a variety of colorants used in different industries, such as textiles, plastics, and printing inks.
Used in Insecticide Manufacturing:
As an intermediate in the manufacturing of insecticides, 4'-BROMO-2'-NITROACETANILIDE plays a crucial role in the development of effective pest control agents. Its chemical structure can be modified to create compounds with specific insecticidal properties, targeting various pests and improving crop protection.
Used in Biologically Active Compounds Synthesis:
4'-BROMO-2'-NITROACETANILIDE is employed as a starting material for the synthesis of biologically active compounds. Its unique structure and reactivity enable the development of compounds with potential applications in medicine, agriculture, and other fields.
Used in Fine Chemicals Production:
In the production of fine chemicals, 4'-BROMO-2'-NITROACETANILIDE serves as an important intermediate. Its versatility in chemical reactions allows for the synthesis of a wide range of specialty chemicals used in various applications, such as fragrances, flavorings, and other high-value products.

InChI:InChI=1/C8H7BrN2O3/c1-5(12)10-7-3-2-6(9)4-8(7)11(13)14/h2-4H,1H3,(H,10,12)

Upstream product

• 103-88-8 4-bromoacetanilide 
• 17983-59-4 acetic acid-(2-nitro-4-trimethylsilanyl-anilide) 
• 552-32-9 o-nitroacetanilide 
• 7697-37-2 nitric acid 
• 875-51-4 4-Bromo-2-nitroaniline 
• 108-24-7 acetic anhydride 
• 106-40-1 4-bromo-aniline 
• 17983-71-0 N-<4-(trimethylsilyl)phenyl>acetamide 
• 75-36-5 acetyl chloride 
• 88-74-4 2-nitro-aniline 

Downstream Products

• 875-51-4 4-Bromo-2-nitroaniline 
• 36847-83-3 2-amino-4-bromoacetanilide 
• 1964-77-8 5-bromo-2-methylbenzimidazole 
• 68527-67-3 6-bromo-8-nitroquinoline 
• 70873-41-5 4-bromo-2-nitro-1-phenylbenzene 
• 1964-77-8 6-bromo-2-methyl-1H-benzo[d]imidazole 
• 113001-10-8 N-(4-Bromo-2-{[1-(2-nitro-phenyl)-meth-(Z)-ylidene]-amino}-phenyl)-acetamide 
• 31217-97-7 N,N'-(4-bromo-1,2-phenylene)diacetamide 
• 99768-11-3 acetic acid-(4-dihydroxyboranyl-2-nitro-anilide) 
• 1202564-21-3 2-acetamino-5-bromonitrosobenzene 
• 1305348-51-9 2,5⁽⁶⁾-bis(4-cyanophenyl)-1H-benzimidazole 
• 6298-38-0 7-bromo-1-oxido-1,2,4-benzotriazin-1-ium-3-amine 

Relevant academic research and scientific papers

Heterocyclic compounds as FGFR4 inhibitors

The present invention provides heterocyclic compounds as selective inhibitors of fibroblast growth factor receptor 4 (FGFR4), pharmaceutical compositions containing the compounds, methods of preparingthe compounds, and methods of treating cell proliferative diseases, such as cancer, using the compounds of the invention.

Fused tricyclic derivative as FGFR4 inhibitor

The present invention provides a fused tricyclic derivative that is the selective inhibitor of fibroblast growth factor receptor 4 (FGFR4), a pharmaceutical composition containing the compound, a method of making the compound and a method of treating cell proliferative diseases, such as cancer, using the compounds of the invention.

PIII/PV=O Catalyzed Cascade Synthesis of N-Functionalized Azaheterocycles

An organocatalytic method for the modular synthesis of diverse N-aryl and N-alkyl azaheterocycles (indoles, oxindoles, benzimidazoles, and quinoxalinediones) is reported. The method employs a small-ring organophosphorus-based catalyst (1,2,2,3,4,4-hexamethylphosphetane P-oxide) and a hydrosilane reductant to drive the conversion of ortho-functionalized nitroarenes into azaheterocycles through sequential intermolecular reductive C?N cross coupling with boronic acids, followed by intramolecular cyclization. This method enables the rapid construction of azaheterocycles from readily available building blocks, including a regiospecific approach to N-substituted benzimidazoles and quinoxalinediones.

Transition-metal-free mono- or dinitration of protected anilines

An amide-assisted arene nitration is presented, and both mono- and dinitration of protected anilines could be effected by using NaNO2 and NaNO3 as the mono- and bisnitrating agents, respectively. This divergent synthesis is transition-metal- and acid-free, and features a broad substrate scope, low cost, and ortho–para selectivity.

PYRIMIDINE DERIVATIVE, METHOD FOR PREPARING SAME AND USE THEREOF IN MEDICINE

The present invention relates to a pyrimidine derivative, a method for preparing same and use thereof in medicine. In particular, the present invention relates to a pyrimidine derivative represented by general formula (I), a method for preparing same and a pharmaceutically acceptable salt thereof as well as use thereof as a therapeutic agent, in particular as a FGFR4 kinase inhibitor, definitions of each substituent in the general formula (I) being the same as those defined in the description.

3-(Ethoxycarbonyl)-1-(5-methyl-5-(nitrosooxy)hexyl)pyridin-1-ium cation: A green alternative to tert-butyl nitrite for synthesis of nitro-group-containing arenes and drugs at room temperature

Due to their remarkable properties, task-specific ionic liquids have turned out to be progressively popular over the last few years in the field of green organic synthesis. Herein, for the first time, we report that a new task-specific nitrite-based ionic liquid such as 3-(ethoxycarbonyl)-1-(5-methyl-5-(nitrosooxy)hexyl)pyridin-1-ium bis(trifluoromethanesulfonyl)imides (TS-N-IL) derived from biodegradable ethyl nicotinate indeed acted as an efficient and eco-friendly reagent for the synthesis of highly valuable nitroaromatic compounds and drugs including nitroxynil, tolcapone, niclofolan, flutamide, niclosamide and nitrazepam. The bridging of an ionic liquid with nitrite group not only increases the yield and rate of direct C[sbnd]N bond formation reaction but also allows easy product separation and recyclability of a byproduct. Nonvolatile nature, easy synthesis, merely stoichiometric need and mildness are a portion of the extra focal points of TS-N-IL while contrasted with tert-butyl nitrite an outstanding and highly-flammable reagent utilized largely in organic synthesis.

Regioselective nitration of anilines with Fe(NO3)3·9H2O as a promoter and a nitro source

An efficient Fe(NO3)3·9H2O promoted ortho-nitration reaction of aniline derivatives has been developed. This reaction may go through a nitrogen dioxide radical (NO2) intermediate, which is generated by the thermal decomposition of iron(iii) nitrate. The practicality of the present method using nontoxic and inexpensive iron reagents has been shown by the broad substrate scope and applications.

Heterocycle type derivative and preparing method and pharmaceutical application thereof

The invention relates to a novel heterocycle type derivative, a preparing method thereof, a medicine composition containing the derivative and application of the heterocycle type derivative as therapeutic agent, particularly an FGFR4 inhibitor. The preferable compound has a good inhibiting effect on FGFR4.

Pyrimidine derivatives as well as preparation method and medical applications thereof

The invention relates to pyrimidine derivatives as well as a preparation method and medical applications thereof, in particular to pyrimidine derivatives shown as a general formula (I) in the description, a preparation method and medicinal salts thereof and applications of the pyrimidine derivatives and the medicinal salts as therapeutic agents, especially as FGFR4 (fibroblast growth factor receptor 4) kinase inhibitors. Definitions of substituent groups in the general formula (I) are the same as those in the description.

Regioselective ortho-nitration of N-phenyl carboxamides and primary anilines using bismuth nitrate/acetic anhydride

An efficient and one-pot synthetic method for the regioselective ortho-nitration of the N-phenyl carboxamides and primary anilines has been developed by using bismuth nitrate and acetic anhydride as the nitrating reagents. Reaction proceeds at room temperature and results in corresponding ortho-nitrated products in moderate to excellent yields. This method provides an operationally simple, regioselective, and efficient access to synthesize o-nitro anilines under the mild conditions.