881-50-5

Basic information

• Product Name: 4'-BROMO-2'-NITROACETANILIDE
• Synonyms: 4'-BROMO-2'-NITROACETANILIDE;4-BROMO-2-NITROACETANILIDE;Acetamide, N-(4-bromo-2-nitrophenyl)-;N-(4-Bromo-2-nitrophenyl)acetamide;N-(2-Nitro-4-bromophenyl)acetamide;N-(4-bromo-2-nitro-phenyl)ethanamide;N-(4-Bromo-2-nitrophenyl)
• CAS NO: 881-50-5
• Molecular Formula: C₈H₇BrN₂O₃
• Molecular Weight: 259.06
• Product Categories: Anilines, Amides & Amines;Bromine Compounds;Nitro Compounds
• Mol File: 881-50-5.mol
• Article Data: 22

Chemical Properties

• Melting Point: 102-104°C
• Boiling Point: 416.8°C at 760 mmHg
• Flash Point: 205.9°C
• Appearance: /
• Density: 1.72g/cm³
• Vapor Pressure: 3.72E-07mmHg at 25°C
• Refractive Index: 1.647
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 12.96±0.70(Predicted)
• CAS DataBase Reference: 4'-BROMO-2'-NITROACETANILIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4'-BROMO-2'-NITROACETANILIDE(881-50-5)
• EPA Substance Registry System: 4'-BROMO-2'-NITROACETANILIDE(881-50-5)

Safety Data

• Hazardous Substances Data: 881-50-5(Hazardous Substances Data)

Usage

General Description

4’-Bromo-2’-nitroacetanilide, also known as 4-bromo-2-nitroacetanilide or bromonitroaniline, is a chemical compound primarily used in the synthesis of pharmaceuticals and organic compounds. With the molecular formula C8H7BrN2O3, it is a yellowish crystalline solid that is insoluble in water but soluble in organic solvents. 4'-BROMO-2'-NITROACETANILIDE is commonly used as a building block for the synthesis of various heterocyclic compounds, dyes, pigments, and pharmaceuticals. It is also employed as an intermediate in the manufacturing of insecticides, biologically active compounds, and other fine chemicals. Additionally, 4’-Bromo-2’-nitroacetanilide is known for its potential toxic and hazardous effects, and thus special care and precautions are required when handling and using this compound.

InChI:InChI=1/C8H7BrN2O3/c1-5(12)10-7-3-2-6(9)4-8(7)11(13)14/h2-4H,1H3,(H,10,12)

Upstream product

• 17983-59-4 acetic acid-(2-nitro-4-trimethylsilanyl-anilide) 
• 103-88-8 4-bromoacetanilide 
• 7697-37-2 nitric acid 
• 875-51-4 4-Bromo-2-nitroaniline 
• 75-36-5 acetyl chloride 
• 108-24-7 acetic anhydride 
• 106-40-1 4-bromo-aniline 
• 552-32-9 o-nitroacetanilide 
• 88-74-4 2-nitro-aniline 
• 17983-71-0 N-<4-(trimethylsilyl)phenyl>acetamide 

Downstream Products

• 68527-67-3 6-bromo-8-nitroquinoline 
• 99768-11-3 acetic acid-(4-dihydroxyboranyl-2-nitro-anilide) 
• 1305348-51-9 2,5⁽⁶⁾-bis(4-cyanophenyl)-1H-benzimidazole 
• 6298-38-0 7-bromo-1-oxido-1,2,4-benzotriazin-1-ium-3-amine 
• 5367-49-7 N-(4-morpholinyl-2-nitrophenyl)acetamide 

Relevant articles and documents

Heterocyclic compounds as FGFR4 inhibitors

The present invention provides heterocyclic compounds as selective inhibitors of fibroblast growth factor receptor 4 (FGFR4), pharmaceutical compositions containing the compounds, methods of preparingthe compounds, and methods of treating cell proliferative diseases, such as cancer, using the compounds of the invention.

PIII/PV=O Catalyzed Cascade Synthesis of N-Functionalized Azaheterocycles

An organocatalytic method for the modular synthesis of diverse N-aryl and N-alkyl azaheterocycles (indoles, oxindoles, benzimidazoles, and quinoxalinediones) is reported. The method employs a small-ring organophosphorus-based catalyst (1,2,2,3,4,4-hexamethylphosphetane P-oxide) and a hydrosilane reductant to drive the conversion of ortho-functionalized nitroarenes into azaheterocycles through sequential intermolecular reductive C?N cross coupling with boronic acids, followed by intramolecular cyclization. This method enables the rapid construction of azaheterocycles from readily available building blocks, including a regiospecific approach to N-substituted benzimidazoles and quinoxalinediones.

3-(Ethoxycarbonyl)-1-(5-methyl-5-(nitrosooxy)hexyl)pyridin-1-ium cation: A green alternative to tert-butyl nitrite for synthesis of nitro-group-containing arenes and drugs at room temperature

Due to their remarkable properties, task-specific ionic liquids have turned out to be progressively popular over the last few years in the field of green organic synthesis. Herein, for the first time, we report that a new task-specific nitrite-based ionic liquid such as 3-(ethoxycarbonyl)-1-(5-methyl-5-(nitrosooxy)hexyl)pyridin-1-ium bis(trifluoromethanesulfonyl)imides (TS-N-IL) derived from biodegradable ethyl nicotinate indeed acted as an efficient and eco-friendly reagent for the synthesis of highly valuable nitroaromatic compounds and drugs including nitroxynil, tolcapone, niclofolan, flutamide, niclosamide and nitrazepam. The bridging of an ionic liquid with nitrite group not only increases the yield and rate of direct C[sbnd]N bond formation reaction but also allows easy product separation and recyclability of a byproduct. Nonvolatile nature, easy synthesis, merely stoichiometric need and mildness are a portion of the extra focal points of TS-N-IL while contrasted with tert-butyl nitrite an outstanding and highly-flammable reagent utilized largely in organic synthesis.