518993-55-0Relevant academic research and scientific papers
A concise synthesis of substituted thiourea derivatives in aqueous medium
Maddani, Mahagundappa R.,Prabhu, Kandikere R.
supporting information; experimental part, p. 2327 - 2332 (2010/07/02)
(Figure Presented) An efficient method for the synthesis of symmetrical and unsymmetrical substituted thiourea derivatives by means of simple condensation between available building blocks such as amines and carbon disulfide in aqueous medium is presented. This protocol works smoothly with aliphatic primary amines to afford various di- and trisubstituted thiourea derivatives. The present method is also useful in synthesizing various substituted 2-mercapto imidazole heterocycles. This method proceeds through a xanthate (amino dithiol deivative) intermediate, unlike isothiocyanate as in an earlier known method.
Highly efficient and catalyst-free synthesis of unsymmetrical thioureas under solvent-free conditions
Halimehjani, Azim Ziyaei,Pourshojaei, Yaghoub,Saidi, Mohammad R.
scheme or table, p. 32 - 34 (2009/04/10)
A highly efficient and simple synthesis of unsymmetrical thioureas is reported based on the reaction of readily synthesized dithiocarbamates with amines, without using any catalyst under solvent-free conditions. The short reaction time, high yields, and s
