519183-78-9Relevant articles and documents
A new route for the construction of the AB-ring core of Taxol
Shimada, Yumi,Nakamura, Makoto,Suzuka, Toshimasa,Matsui, Junji,Tatsumi, Ryo,Tsutsumi, Ken,Morimoto, Tsumoru,Kurosawa, Hideo,Kakiuchi, Kiyomi
, p. 1401 - 1403 (2007/10/03)
A new method for the construction of the AB-ring core of Taxol was developed utilizing a new skeletal transformation protocol as a pivotal step. The acid-catalyzed rearrangement of the cyclopentenone-allene photoadduct gave a bridged seven-membered ketone, which was easily transformed, using the intramolecular Suzuki reaction and the oxidative cleavage of the vicinal diol, to the bicyclic diketone.