519183-90-5

Upstream product

• 519183-88-1 tert-butyl-(9,9-dimethyl-1,2,3,4,5,6,7,8-octahydro-4,8-methano-azulen-5-yloxy)-dimethyl-silane 
• 519183-86-9 7-allyl-4-(tert-butyl-dimethyl-silanyloxy)-8,8-dimethyl-bicyclo[3.2.1]octan-6-one 
• 519183-84-7 [4-(tert-butyl-dimethyl-silanyloxy)-8,8-dimethyl-bicyclo[3.2.1]oct-6-yl]-methanol 
• 519183-82-5 tert-butyl-(8,8-dimethyl-7-methylene-bicyclo[3.2.1]oct-2-yloxy)-dimethyl-silane 
• 519183-74-5 4-(tert-butyl-dimethyl-silanyloxy)-8,8-dimethyl-bicyclo[3.2.1]octan-6-one 
• 519183-97-2 9,9-dimethyl-1,2,3,4,5,6,7,8-octahydro-4,8-methano-azulen-5-ol 
• 519183-99-4 9,9-dimethyl-2,3,4,6,7,8-hexahydro-1H-4,8-methano-azulen-5-one 
• 519183-78-9 5-isopropyl-7-methylene-bicyclo[3.2.0]heptan-2-one 
• 519183-94-9 8,8-dimethyl-7-methylene-bicyclo[3.2.1]octan-2-ol 
• 519183-76-7 8,8-dimethyl-7-methylene-bicyclo[3.2.1]octan-2-one 
• 519183-73-4 9,9-dimethyl-5-methylene-1,2,3,4,5,6,7,8-octahydro-4,8-methano-azulene 

Relevant academic research and scientific papers

A new route for the construction of the AB-ring core of Taxol

A new method for the construction of the AB-ring core of Taxol was developed utilizing a new skeletal transformation protocol as a pivotal step. The acid-catalyzed rearrangement of the cyclopentenone-allene photoadduct gave a bridged seven-membered ketone, which was easily transformed, using the intramolecular Suzuki reaction and the oxidative cleavage of the vicinal diol, to the bicyclic diketone.