51933-46-1

Upstream product

• 19312-06-2 4,5-dihydro-4,4-dimethyl-2-phenoxazole 
• 123-11-5 4-methoxy-benzaldehyde 

Downstream Products

• 21615-74-7 3-(4-methoxyphenyl)phthalide 
• 86917-44-4 3-(2-chloro-1,1-dimethylethylimino)-1-p-methoxyphenyl-1,3-dihydro-2-benzofuran 
• 86917-44-4 (2-Chloro-1,1-dimethyl-ethyl)-[3-(4-methoxy-phenyl)-3H-isobenzofuran-(1E)-ylidene]-amine 

Relevant academic research and scientific papers

Synthesis and Structure - Activity Relationships of Sweet 2-Benzoylbenzoic Acid Derivatives

Twenty-four analogues of the sweet compound 2-(4-methoxybenzoyl)benzoic acid 1 were synthesized and tasted. The structure-sweet taste relationships were studied by means of principal component analysis and by comparison with the existing sweet receptor models. Three possible glucophores were identified, which could correspond to the sites B, E1, and E2 of the Tinti - Nofre model. Some similarities between this class of compounds and isovanillic sweeteners were found.

Structure of Alcohols obtained by Reaction of Aldehydes and Ketones with ortho-Lithiated Oxazolines

The reaction of aldehydes with ortho-lithiated oxazolines typically gives secondary alcohols.Exceptionally, a case is described of the formation of a primary alcohol by the opening of the oxazoline ring.The reaction of ketones with ortho-lithiated oxazolines, in contrast to reports in the literature, typically gives primary alcohols, by opening of the oxazoline ring, and not the reported tertiary alcohols.The proposed structures are substantiated by the preparation of derivatives and, particularly, by consideration of the 13C n.m.r. spectra.