51934-38-4

Basic information

• Product Name: 6-bromonaphthalene-1-carboxylic acid
• Synonyms: 6-bromonaphthalene-1-carboxylic acid;6-Bromo-1-naphthoic acid
• CAS NO: 51934-38-4
• Molecular Formula: C₁₁H₇BrO₂
• Molecular Weight: 251.0761
• Mol File: 51934-38-4.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 421.194 °C at 760 mmHg
• Flash Point: 208.531 °C
• Appearance: /
• Density: 1.649 g/cm³
• CAS DataBase Reference: 6-bromonaphthalene-1-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 6-bromonaphthalene-1-carboxylic acid(51934-38-4)
• EPA Substance Registry System: 6-bromonaphthalene-1-carboxylic acid(51934-38-4)

Safety Data

• Hazardous Substances Data: 51934-38-4(Hazardous Substances Data)

Usage

General Description

6-bromonaphthalene-1-carboxylic acid is a chemical compound that belongs to a class of organic compounds known as bromobenzenes. The molecular formula of this compound is C11H7BrO2. It is characterized by a bromo group attached to a naphthalene ring that is further substituted with a carboxylic acid group. Its physical and chemical properties make it useful in various applications. It is often used as an intermediate in pharmaceuticals and other chemical reactions. More research is needed to fully understand its biological effects and environmental fate.

Upstream product

• 177846-05-8 6-bromo-1,2-dihydronaphthalene-1-carboxylic acid 
• 14062-25-0 Ethyl 4-bromophenylacetate 
• 81-84-5 1,8-Naphthalic anhydride 
• 24050-49-5 3-bromonaphthalic-1,8-anhydride 
• 91135-41-0 5-Cyan-naphthylamin-⁽²⁾ 
• 91804-23-8 5-cyanonaphthalene-2-carboxylic acid methyl ester 
• 94629-28-4 5-Cyan-naphthoesaeure-⁽²⁾-azid 
• 91493-88-8 5-Cyan-naphthoesaeure-⁽²⁾-hydrazid 
• 67878-76-6 5-bromo-2-naphthalenecarboxylic acid methyl ester 
• 91065-16-6 6-bromo-1-cyanonaphthalene 

Downstream Products

• 86456-56-6 6-bromo-1-naphthaldehyde 
• 33626-98-1 methyl 6-bromo-2-naphthoate 
• 91804-22-7 6-Cyan-naphthoesaeure-(1)-methylester 

Relevant articles and documents

Concise Synthesis of Natural Phenylphenalenone Phytoalexins and a Regioisomer

Concise total syntheses of the natural phytoalexins 2-hydroxy-8-(4-hydroxyphenyl)phenalen-1-one (1), 2-hydroxy-8-(3,4-dihydroxyphenyl)phenalen-1-one (2), and hydroxyanigorufone (4), together with regioisomer 3 are accomplished in 11 or 12 steps. The synthetic strategy features a Friedel-Crafts acylation to construct the 1H-phenalen-1-one tricyclic core followed by a Suzuki cross-coupling to obtain the target compounds.

A rapid, large-scale synthesis of a potent cholecystokinin (CCK) 1R receptor agonist

The development of a scalable synthesis of a potent cholecystokinin (CCK) IR receptor agonist is described. The focus on a rapid short-term delivery rather than longer-term development allowed for the preparation of multihundred gram quantities to support

The mercury-mediated decarboxylation (Pesci reaction) of naphthoic anhydrides investigated by microwave synthesis

The mercury-mediated decarboxylation (Pesci reaction) of several substituted naphthoic anhydrides has been investigated by microwave synthesis. A laboratory microwave reactor was found to be ideal for small-scale preparations of this slow reaction, reducing reaction times from typically four days to less than 1 h for the three-step process. The ionic reaction medium rapidly heated to high temperatures under microwave heating and could be efficiently maintained by low microwave power settings. Generation of stoichiometric CO2 was safely contained within the reaction tubes. A simplified reaction procedure has been developed. For substituted naphthoic anhydrides, 1H NMR analysis of the naphthoate ester derivatives indicated no change in the regioisomer ratio compared to previously reported thermal values.