51947-86-5

Upstream product

• 2942-59-8 2-chloronicotinic acid 
• 4394-09-6 2-((4-methoxyphenyl)amino)nicotinic acid 
• 104-94-9 4-methoxy-aniline 

Downstream Products

• 77692-20-7 2-(4-methoxyanilino)-3-pyridinecarbohydrazide 
• 145255-69-2 1-(4-Methoxy)phenyl-2H-pyrido[2,3-d][1,3]oxazine-2,4(1H)-dione 
• 77692-24-1 N-tosylhydrazide 
• 77692-23-0 2-(4-Methoxy-phenylamino)-nicotinic acid [1-phenyl-eth-(Z)-ylidene]-hydrazide 
• 77692-21-8 2-(4-Methoxy-phenylamino)-nicotinic acid [1-phenyl-meth-(E)-ylidene]-hydrazide 
• 77692-25-2 2-(4-Methoxy-phenylamino)-nicotinic acid cyclohexylidene-hydrazide 
• 77692-22-9 2-(4-Methoxy-phenylamino)-nicotinic acid [1-methyl-prop-(Z)-ylidene]-hydrazide 
• 115892-10-9 4-Allyloxy-1-(4-methoxy-phenyl)-1H-[1,8]naphthyridin-2-one 
• 115892-04-1 4-hydroxy-1-(4-methoxyphenyl)-1,8-naphthyridin-2(1H)-one 
• 115891-49-1 2-[Acetyl-(4-methoxy-phenyl)-amino]-nicotinic acid methyl ester 

Relevant academic research and scientific papers

Antiallergy Agents. 1. Substituted 1,8-Naphthyridin-2(1H)-ones as Inhibitors of SRS-A Release

A novel class of antiallergy agents, the substituted 1,8-naphthyridin-2(1H)-ones, is described.The present compounds are orally active, potent inhibitors of allergic and nonallergic bronchospasm in animal models.Structure-activity studies of the lead compound in this sereis, 1-phenyl-3-n-butyl-4-hydroxynaphthyridin-2(1H)-one (11), identified three compounds of interest, 1-phenyl-3-(2-propenyl)-4-acetoxy-1,8-naphthyridin-2(1H)-one (12), 1-(3'-chlorophenyl)-3-(2-propenyl)-4-acetoxy-1,8-naphthyridin-2(1H)-one (87), and 1-(3'-methoxyphenyl)-3-(2-propenyl)-4-acetoxy-1,8-naphthyridin-2(1H)-one (89).The mechanism of antiallergy activity may involve inhibition of the release of the sulfidopeptide leukotrienes. 1-Phenyl-3-(2-propenyl)-4-acetoxy-1,8-naphthyridin-2(1H)-one, Sch 33303 (12), was selected for preclinical development as an antiallergy agent.