51953-14-1

Basic information

• Product Name: 2,4-Pyrimidinediol (9CI)
• Synonyms: 2,4-Pyrimidinediol (9CI)
• CAS NO: 51953-14-1
• Molecular Formula: C4H4N2O2
• Molecular Weight: 112.08676
• Product Categories: PYRIMIDINE
• Mol File: 51953-14-1.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• Water Solubility: 3.322g/L(20 oC)
• CAS DataBase Reference: 2,4-Pyrimidinediol (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-Pyrimidinediol (9CI)(51953-14-1)
• EPA Substance Registry System: 2,4-Pyrimidinediol (9CI)(51953-14-1)

Safety Data

• Hazardous Substances Data: 51953-14-1(Hazardous Substances Data)

Usage

Type of compound

pyrimidine derivative

Functional group

diol

Common uses

building block in organic synthesis and chemical research

Potential applications

pharmaceutical and agrochemical industries, material science, and biochemistry

Available grades and purities

varies for different applications

Safety precautions

handle with care to avoid potential hazards

Upstream product

• 59696-81-0 5'-Desoxy-2',3'-O-isopropylidenuridin-5'-carbonitril 
• 77287-34-4 formamide 
• 105-56-6 ethyl 2-cyanoacetate 
• 79-20-9 acetic acid methyl ester 
• 57-13-6 urea 
• 109-94-4 formic acid ethyl ester 
• 7306-79-8 2,4-bis(benzyloxy)pyrimidine 
• 66-22-8 uracil 

Downstream Products

• 504-07-4 5,6-dhydrouracil 
• 696-07-1 5-iodo-2,4-pyrimidine-diol 

Relevant articles and documents

Green preparation method of palatinib hydrochloride (by machine translation)

The invention belongs to the technical field of chemical synthesis of medicines, and belongs to the technical field of pharmaceutical chemistry. The invention particularly relates to a green preparation method. The o-methyl aniline and N - chlorosuccinimide are chlorinated to obtain 2 - methyl -5 - chloro- aniline; the 6 - chlorine - 222H-indole hydrochloride is obtained by reacting with the nitrous acid compound; N-methyl -6 -chloro - 222H-indole; under the participation of dimethyl sulfoxide, 3 - 2-dimethyl 3 - chlorine -6 - 222H-indazole; and the like. A reaction with 2 - chloro -4 - amino - pyrimidine and iodomethane gave N - (2 -chloropyrimidine -4 -yl) - N N-methyl -2, 3 -dimethyl - 222H-indazole -6 - amine; and finally, a pimatinib hydrochloride salt was obtained by reaction with 3 - sulfanilide -4 - methyl - aniline. The method is low in raw material price, simple to operate, low in operation risk, capable of avoiding waste acid generation, high in reaction yield, and high in purity. (by machine translation)

Alpha-substituted pyrimidine-thioalkyl and alkylether compounds as inhibitors of viral reverse transcriptase

The subject invention relates to pyrimidine-thioalkyl and alkylether compounds of Formula (I) and pyrimidine-thioalkyl and alkylethers of Formula (IA), namely the compounds of Formula (I) where R 4 is selected from the group consisitng of --H or --NR 15 R 16 where R 15 is --H and R 16 is --H, C 1 -C 6 alkyl, NH 2 or R 15 and R 16 taken together with the --N form 1-pyrrolidino, 1-morpholino or 1-piperidino; and R 6 is selected from the group consisting of --H, or halo (preferably --Cl); with the overall proviso that R 4 and R 6 are not both --H. The compounds of Formula (IA) are useful in the treatment of individuals who are HIV positive being inhibitors of viral reverse transcriptase. STR1

Preparation of 1-(2,3-dideoxy-β-D-glycero-pent-2-enofuranosyl)thymine (d4T) and 2',3'-dideoxyadenosine (ddA): General methods for the synthesis of 2',3'-olefinic and 2',3'-dideoxy nucleoside analogues active against HIV

-