51954-52-0Relevant academic research and scientific papers
Convenient and Inexpensive Route to Sulfonylated Pyridines via S N Ar Reaction of Electron-Rich Pyridines by Iron Catalysis
Chen, Fei,Chacón-Huete, Franklin,El-Husseini, Hassan,Forgione, Pat
, p. 1914 - 1920 (2018)
Sulfonylated pyridines were synthesized in moderate to excellent yields, with a wide scope of substituted pyridines and sulfinate salts as starting materials, by an iron-catalyzed S N Ar reaction. This new methodology exhibits advantages for the synthesis of these useful substrates, such as the use of a readily available, inexpensive catalyst, prevention of the disproportionation of the sulfinate salts, and, more importantly, providing access to electron-rich pyridine substrates.
5-Alkyl-2-(p-tolylsulfonyl)pyridines by Regioselective Cyano Cycloaddition
Rueffer, Ursula,Breitmaier, Eberhard
, p. 623 - 625 (2007/10/02)
5-Alkyl-2-(p-tolylsulfonyl)pyridines 4 are obtained in good yields at room temperature by cyano cycloaddition of p-toluenesulfonyl cyanide 2 to 2-alkyl-1-ethoxy-1,3-butadienes 1, followed by aromatization of the intermediate dihydropyridine 3 via an
