5196-20-3

Usage

Uses

Used in Pharmaceutical Industry:
1,3-dihydro-6-methylfuro[3,4-c]pyridin-7-ol is used as an intermediate in the synthesis of pyridoxine (vitamin B6) for its essential role in various metabolic processes in the human body. Vitamin B6 is vital for the proper functioning of the nervous system, immune system, and the synthesis of amino acids, which are the building blocks of proteins.
Used in Vitamin Production:
1,3-dihydro-6-methylfuro[3,4-c]pyridin-7-ol is used as a precursor in the production of vitamin B6, which is an essential nutrient that plays a critical role in the metabolism of carbohydrates, fats, and proteins. It also supports the production of neurotransmitters, which are essential for proper brain function and the regulation of mood.

InChI:InChI=1/C8H9NO2/c1-5-8(10)7-4-11-3-6(7)2-9-5/h2,10H,3-4H2,1H3

Upstream product

• 65-23-6 5-hydroxy-6-methyl-3,4-pyridinedimethanol 
• 880-91-1 1-ethoxy-7-hydroxy-6-methyl-1,3-dihydrofuro[3,4-c]pyridin-7-ol 
• 92757-43-2 6-methyl-7-(trimethylsilyl)-1,3-dihydrofuro<3,4-c>pyridin-5-oxid 
• 856412-06-1 6-methyl-7-(dimethylisopropoxysilyl)-1,3-dihydrofuro[3,4-c]pyridine 
• 856412-04-9 3,3-bis(dimethylisopropoxysilyl)-di-2-propynyl ether 
• 856412-05-0 6-methyl-4,7-bis(dimethylisopropoxysilyl)-1,3-dihydrofuro[3,4-c]pyridine 
• 1708-29-8 2,5-dihydrofuran 
• 24201-52-3 4-methyl-5-butoxy1,3-oxazole 
• 19104-68-8 4-methyl-5-propoxyoxazole 
• 5006-20-2 5-ethoxy-4-methyl-oxazole 
• 92757-48-7 6-methyl-4-(trimethylsilyl)-1,3-dihydrofuro<3,4-c>pyridin-7-carbonsaeure-aethylester 
• 92772-76-4 6-methyl-1,3-dihydrofuro<3,4-c>pyridin-7-carbaminsaeure-(tert-butyl)ester 
• 92757-50-1 6-methyl-1,3-dihydrofuro<3,4-c>pyridin-7-carbonsaeure-aethylester 
• 92757-51-2 6-methyl-1,3-dihydrofuro<3,4-c>pyridin-7-carbonsaeure 

Relevant academic research and scientific papers

An improved synthesis of pyridoxine via [2+2+2] cyclization of acetylenes and nitriles

An improved synthesis of pyridoxine (vitamin B6) is reported. The key step involves the light-promoted [2+2+2] cyclization of 3,3-bissilyl-di-2-propynyl ethers and acetonitrile in the presence of [cpCo(cod)] (1 mol%) as a catalyst. Convenient oxidation and iodination procedures are elaborated to transfer 3-silylpyridines into corresponding 3-hydroxy- and 3-iodo-derivatives.

Synthesis of [13C3]-B6 vitamers labelled at three consecutive positions starting from [13C3]-propionic acid

[13C3]-labelled vitamers (PN, PL and PM) of the B6 group were prepared starting from [13C3]-propionic acid. [13C3]-PN was synthesized in ten linear steps with an overall yield of 17%. Hereby, higher alkyl homologues of involved esters showed a positive impact on the reaction outcome of the intermediates in the chosen synthetic route. Oxidation of [13C3]-PN to [13C3]-PL was undertaken using potassium permanganate and methylamine followed by acid hydrolysis of the imine derivative. [13C3]-PM could be prepared from the oxime derivative of [13C3]-PN by hydrogenation with palladium.