5196-20-3

Basic information

• Product Name: 1,3-dihydro-6-methylfuro[3,4-c]pyridin-7-ol
• Synonyms: 1,3-dihydro-6-methylfuro[3,4-c]pyridin-7-ol;Einecs 225-981-4;3-methyl-8-oxa-4-azabicyclo[4.3.0]nona-1,3,5-trien-2-ol;Pyridoxine Cyclic Ether IMpurity;6-Methyl-1H,3H-furo[3,4-c]pyridin-7-ol;6-Methyl-1,3-dihydrofuro[3,4-c]pyridin-7-ol
• CAS NO: 5196-20-3
• Molecular Formula: C₈H₉NO₂
• Molecular Weight: 151.16256
• EINECS: 225-981-4
• Product Categories: Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 5196-20-3.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 358.5 °C at 760 mmHg
• Flash Point: 170.6 °C
• Appearance: /
• Density: 1.286±0.06 g/cm3 (20 ºC 760 Torr)
• Vapor Pressure: 1.23E-05mmHg at 25°C
• Refractive Index: 1.6
• Storage Temp.: 2-8°C
• PKA: 5.49±0.20(Predicted)
• CAS DataBase Reference: 1,3-dihydro-6-methylfuro[3,4-c]pyridin-7-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-dihydro-6-methylfuro[3,4-c]pyridin-7-ol(5196-20-3)
• EPA Substance Registry System: 1,3-dihydro-6-methylfuro[3,4-c]pyridin-7-ol(5196-20-3)

Safety Data

• RIDADR: UN 2811 6.1 / PGIII
• Hazardous Substances Data: 5196-20-3(Hazardous Substances Data)

Usage

Uses

6-Methyl-1,3-dihydrofuro[3,4-c]pyridin-7-ol is an intermediate used in the preparation of pyridoxine (vitamin B6).

InChI:InChI=1/C8H9NO2/c1-5-8(10)7-4-11-3-6(7)2-9-5/h2,10H,3-4H2,1H3

Upstream product

• 65-23-6 5-hydroxy-6-methyl-3,4-pyridinedimethanol 
• 880-91-1 1-ethoxy-7-hydroxy-6-methyl-1,3-dihydrofuro[3,4-c]pyridin-7-ol 
• 856412-06-1 6-methyl-7-(dimethylisopropoxysilyl)-1,3-dihydrofuro[3,4-c]pyridine 
• 1708-29-8 2,5-dihydrofuran 
• 24201-52-3 4-methyl-5-butoxy1,3-oxazole 
• 19104-68-8 4-methyl-5-propoxyoxazole 
• 5006-20-2 5-ethoxy-4-methyl-oxazole 
• 92757-48-7 6-methyl-4-(trimethylsilyl)-1,3-dihydrofuro<3,4-c>pyridin-7-carbonsaeure-aethylester 
• 92772-76-4 6-methyl-1,3-dihydrofuro<3,4-c>pyridin-7-carbaminsaeure-(tert-butyl)ester 
• 92757-50-1 6-methyl-1,3-dihydrofuro<3,4-c>pyridin-7-carbonsaeure-aethylester 
• 92757-51-2 6-methyl-1,3-dihydrofuro<3,4-c>pyridin-7-carbonsaeure 
• 92757-47-6 4-<3-(trimethylsilyl)-2-propinyl>oxy-2-butinsaeure-aethylester 
• 92757-46-5 4-<3-(trimethylsilyl)-2-propinyl>oxy-2-butinsaeure 
• 92757-80-7 6-methyl-4,7-bis(trimethylsilyl)-1,3-dihydrofuro<3,4-c>pyridin 

Relevant articles and documents

An improved synthesis of pyridoxine via [2+2+2] cyclization of acetylenes and nitriles

An improved synthesis of pyridoxine (vitamin B6) is reported. The key step involves the light-promoted [2+2+2] cyclization of 3,3-bissilyl-di-2-propynyl ethers and acetonitrile in the presence of [cpCo(cod)] (1 mol%) as a catalyst. Convenient oxidation and iodination procedures are elaborated to transfer 3-silylpyridines into corresponding 3-hydroxy- and 3-iodo-derivatives.

Cobalt-catalyzed cycloaddition of alkynes and nitriles to pyridines: A new route to pyridoxine (vitamin B6)

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