24201-52-3

Basic information

• Product Name: Oxazole, 5-butoxy-4-methyl-
• CAS NO: 24201-52-3
• Molecular Formula: C8H13NO2
• Molecular Weight: 155.197
• Mol File: 24201-52-3.mol

Chemical Properties

• CAS DataBase Reference: Oxazole, 5-butoxy-4-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Oxazole, 5-butoxy-4-methyl-(24201-52-3)
• EPA Substance Registry System: Oxazole, 5-butoxy-4-methyl-(24201-52-3)

Safety Data

• Hazardous Substances Data: 24201-52-3(Hazardous Substances Data)

Upstream product

• 774596-25-7 N-n-butoxyoxalylalanine n-butyl ester 
• 44924-99-4 DL-alanine butyl ester 
• 77287-34-4 formamide 
• 19255-82-4 1,1-dibutoxy-2-propanone 
• 1493793-58-0 C₁₃H₂₁NO₄ 
• 23429-13-2 5-butoxy-4-methyl-oxazole-2-carboxylic acid 
• 613-29-6 N-Dibutylaniline 
• 33140-30-6 2-isocyano-propionic acid butyl ester 
• 1860-26-0 tri-(2-ethyl-n-hexyl)amine 
• 86965-96-0 N-formylalanine butyl ester 

Downstream Products

• 58-56-0 pyridoxal hydrochloride 
• 5196-20-3 7-hydroxy-6-methyl-1,3-dihydrofuro<3,4-c>pyridin 

Relevant articles and documents

Synthesis of [13C3]-B6 vitamers labelled at three consecutive positions starting from [13C3]-propionic acid

[13C3]-labelled vitamers (PN, PL and PM) of the B6 group were prepared starting from [13C3]-propionic acid. [13C3]-PN was synthesized in ten linear steps with an overall yield of 17%. Hereby, higher alkyl homologues of involved esters showed a positive impact on the reaction outcome of the intermediates in the chosen synthetic route. Oxidation of [13C3]-PN to [13C3]-PL was undertaken using potassium permanganate and methylamine followed by acid hydrolysis of the imine derivative. [13C3]-PM could be prepared from the oxime derivative of [13C3]-PN by hydrogenation with palladium.

Method for preparing oxazole compound

The invention relates to a method for preparing an oxazole compound. The method comprises the steps: adding an assistant represented by a formula (I) or (II) or (III) into an organic solvent and organic alkali (especially triethylamine), dropwise adding an organic solution of phosgene or diphosgene or triphosgene to carry out cyclization reaction with a compound (IV), and thus obtaining the product (V) at high yield and greatly inhibiting the generation of byproducts. The reaction conditions are mild, and compared with a method without addition of additives, the method provided by the invention can improve the yield of the product (V) to 95% or above and reduce the yield of byproducts by 10% or above.

Synthesis of 4-methyl-5- [...] method

The invention discloses a method for synthesizing 4-methyl-5-alkoxyl oxazole, the method comprises a step b or a step a to the step b in a synthesis route, the synthesis route is shown as the follows, the step a is characterized in that 1,1-dialkoxy acetone is reacted to acetyl halides to generate 1-alcoxyl-1-halogenated acetone; the step b is characterized in that 1-alcoxyl-halogenated acetone is performed a cyclization reaction with methanamide to generate 4-methyl-5-alkoxyl oxazole; wherein the substituted group R is C2-C12 alkyl, and the substituted group X is a halogen element. The synthetic method has the advantages of simple operation, easy acquisition and small toxicity of raw material, high reaction yield and less pollution, and the industrial large production requirement can be satisfied.

Improved oxazole Method for the Practical and Efficient Preparation of Pyridoxine Hydrochloride (Vitamin B6)

Vitamin B6, a well-studied vitamin B, has been synthesized using an oxazole method for the past 20 years. The oxazole method provided 56.2% overall yield but also generated safety, environmental, and health problems, such as using toxic benzene as solvent and unstable, corrosive, and pollutive HCl and POCl3 as reagents. To use the same equipment but the least amount of toxic agents, we developed new reaction conditions for the early steps. For example, we successfully replaced toxic HCl/benzene conditions with NaHSO4/PhCH3 conditions and also developed a novel and efficient dehydrating agent trichloroisocyanuric acid/Ph3P/Et 3N to synthesize the key intermediate 5-butoxy-4-methyl oxazole, instead of using phosphorus oxychloride. These improvements resolved safety, waste avoidance, and workup issues that plagued the previous methodologies. Our process comprised six easy synthetic steps and generated vitamin B6 with 99.4% purity in 56.4% overall yield.

Process for the preparation of substituted oxazoles

The present invention relates to a process for preparing 5-alkoxy-substituted oxazoles, in particular for preparing 4-methyl-5-alkoxy-substituted oxazoles and also a process for preparing pyridoxine derivatives.

Continuous preparation of substituted oxazoles

The present invention relates to a process for continuously preparing 5-alkoxy-substituted oxazoles, in particular for continuously preparing 4-methyl-5-alkoxy-substituted oxazoles and also a process for preparing pyridoxine derivatives.

Continuous preparation of substituted oxazoles

The present invention relates to a process for continuously preparing 5-alkoxy-substituted oxazoles, in particular for continuously preparing 4-methyl-5-alkoxy-substituted oxazoles and also a process for preparing pyridoxine derivatives.

Process for the preparation of substituted oxazoles

The present invention relates to a process for preparing 5-alkoxy-substituted oxazoles, in particular for preparing 4-methyl-5-alkoxy-substituted oxazoles and also a process for preparing pyridoxine derivatives.

Process for the preparation of substituted oxazoles

A process for the preparation of 5-alkoxy-substituted oxazoles, in particular for the preparation of 4-methyl-5-alkoxy-substituted oxazoles, and a process for the preparation of pyridoxine derivatives are described.

Process for the continuous preparation of substituted oxazoles

The present invention relates to a process for the continuous preparation of 5-alkoxy-substituted oxazoles, in particular for the continuous preparation of 4-methyl-5-alkoxy-substituted oxazoles, and to a process for preparing pyridoxine derivatives.