Welcome to LookChem.com Sign In|Join Free


  • or


Post Buying Request

5197-66-0 Suppliers

Recommended suppliersmore

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier

5197-66-0 Usage


2-[2-[2-(2-chloroethoxy)ethoxy]ethoxy]ethanol, also known as a polyethylene glycol derivative, is a versatile compound with unique properties that make it suitable for various applications in the pharmaceutical and medical imaging industries. Its molecular structure allows for the formation of novel glycolipids and PET imaging agents, showcasing its potential in both therapeutic and diagnostic realms.


Used in Pharmaceutical Industry:
2-[2-[2-(2-chloroethoxy)ethoxy]ethoxy]ethanol is used as a key component in the synthesis of novel glycolipids for the development of pharmaceutical HIV-1 drugs. These glycolipids have the ability to bind HIV-1 cell surface glycoprotein Gp120, potentially inhibiting the virus's ability to infect host cells and contributing to the fight against HIV-1.
Used in Medical Imaging Industry:
In the field of medical imaging, 2-[2-[2-(2-chloroethoxy)ethoxy]ethoxy]ethanol is utilized in the synthesis of PET (Positron Emission Tomography) imaging agents that specifically target brain β-amyloid. This application is particularly relevant in the diagnosis and monitoring of neurodegenerative diseases, such as Alzheimer's, where the accumulation of β-amyloid plaques is a hallmark feature. By enhancing the imaging of these plaques, this compound aids in the early detection and better understanding of the disease progression.

Check Digit Verification of cas no

The CAS Registry Mumber 5197-66-0 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 5,1,9 and 7 respectively; the second part has 2 digits, 6 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 5197-66:
110 % 10 = 0
So 5197-66-0 is a valid CAS Registry Number.



According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017


1.1 GHS Product identifier

Product name 2-[2-[2-(2-chloroethoxy)ethoxy]ethoxy]ethanol

1.2 Other means of identification

Product number -
Other names 2-{2-[2-(2-chloroethoxy)ethoxy]ethoxy}ethan-1-ol

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:5197-66-0 SDS

5197-66-0Relevant articles and documents

Difunctional derivatives of bis(m-phenylene)- 32-crown-10

Gibson, Harry W.,Nagvekar, Devdatt S.

, p. 1375 - 1384 (2007/10/03)

Optimization studies of the condensation of methyl 3,5-dihydroxybenzoate (1) with tetra(ethylene glycol) dichloride (3) resulted in improvement of the yield of the 1 + 1 cyclization product, 5-carbomethoxy-m-phenylene-16-crown-5 (5), to 67% (HPLC), but no improvement in the yield (28%, HPLC) of the desired 2+2 product, bis(5-carbomethoxy-m-phenylene)-32-crown-10 (4). However, after optimization, a two-step procedure provided improved yields of 4 and this procedure was generalized to afford other difunctional monomers. Condensation of substituted resorcinols with 3 and subsequent transformations yielded substituted (R) 3,5-bis(11-chloro-3,6,9-trioxaundecyl-oxy)benzenes (7, 9-14). Reaction of dihalides 7 (R = COOCH3), 13 (R = CHO), and 12 (R = CH2OSi(Me)2-t-Bu) with methyl 3,5-dihydroxybenzoate (1) produced bis(5-carbomethoxy-m-phenylene)-32-crown-10 (4) (43%), 5-carbomethoxy-m-phenylene-5′-formyl-m′-phenylene-32-crown-10 (15) (32%), and the lactone (16a) (18%, derived from the initially formed 5-hydroxymethyl-m-phenylene-5′-carbomethoxy-m′-phenylene-32-crown-10 (16)), respectively. Subsequent reactions gave the corresponding diacid (17), bis(hydroxymethyl) (19), bis(bromomethyl) (20), diacetyl (18), diformyl (21), bis(p-nitrophenoxymethyl) (22), and di(acetoxymethyl) (23) derivatives.

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)


What can I do for you?
Get Best Price

Get Best Price for 5197-66-0