51975-33-8

Upstream product

• 76639-23-1 2,6,2'-Trimethyl-4'-(2-oxo-2-phenyl-ethyl)-4'H-[1,1']bipyridinyl-4-one 
• 109-06-8 α-picoline 
• 93617-76-6 2-Methyl-4-(2-oxo-2-phenyl-ethyl)-4H-pyridine-1-carboxylic acid phenyl ester 
• 98-86-2 acetophenone 

Relevant academic research and scientific papers

REGIOSELECTIVE ADDITION OF TITANIUM ENOLATES TO 1-ACYLPYRIDINIUM SALTS. A CONVENIENT SYNTHESIS OF 4-(2-OXOALKYL)PYRIDINES

Titanium enolates add to the 4-position of 1-phenoxycarbonylpyridinium salts to give 1,4-dihydropyridines; subsequent aromatization provides 4-(2-oxoalkyl)pyridines.

Synthetic Applications of N-N Linked Heterocycles. Part 8. Regiospecific Synthesis of 4-(α-Acylalkyl)pyridines by Attack of Lithium Enolates of Ketones γ to N-(2,6-Dimethyl-4-oxopyridin-1-yl)pyridinium Salts

The addition of N-(2,6-dimethyl-4-oxopyridin-1-yl)pyridinium salts (2) - (4) to lithium enolates (1) of ketones in tetrahydrofuran at low temperatures gives regiospecifically high yields of 1,4-dihydro-adducts (5) - (7).These are readily isolated and can be decomposed under free-radical conditions, also in high yield, to 4-(α-acylalkyl)pyridines (8) - (10).Unsymmetrical dialkyl ketones give a mixture of two isomeric products, the ratio depending upon reaction conditions and steric factors. αβ-Unsaturated ketones, however, give products resulting from reaction exclusively at the position α' to the carbonyl group.