5198-80-1

Usage

Uses

Used in Chemical Synthesis:
2-Bromo-4-formylthiazole is used as a synthetic intermediate for the preparation of various complex organic molecules. Its unique structure, featuring a bromine atom and a formyl group, allows it to participate in a range of chemical reactions, making it a valuable building block in the synthesis of pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Research Applications:
2-Bromo-4-formylthiazole is used as a research compound for studying the properties and reactivity of organobromine compounds. Its structural attributes provide insights into the behavior of thiazoles in different chemical environments, which can be crucial for the development of new synthetic methods and the understanding of reaction mechanisms.
Used in Pharmaceutical Industry:
2-Bromo-4-formylthiazole is used as a key component in the development of new drugs. Its chemical reactivity and structural features make it a promising candidate for the design of novel therapeutic agents, particularly in the areas of antimicrobial, anticancer, and antiviral treatments. The bromine atom and formyl group can be further modified to enhance the compound's biological activity and selectivity.
Used in Material Science:
2-Bromo-4-formylthiazole is used as a functional group in the synthesis of advanced materials, such as polymers and coordination compounds. Its incorporation into these materials can impart unique properties, such as improved thermal stability, enhanced electrical conductivity, or increased catalytic activity, which can be beneficial for various applications in the fields of electronics, energy storage, and catalysis.

InChI:InChI=1/C4H2BrNOS/c5-4-6-3(1-7)2-8-4/h1-2H

Upstream product

• 888314-10-1 2-bromo-N-methoxy-N-methyl-1,3-thiazole-4-carboxamide 
• 5198-86-7 (2-bromo-1,3-thiazol-4-yl)methanol 
• 100367-77-9 ethyl 2-bromothiazole-4-carboxylate 

Downstream Products

• 1183922-66-8 2-(2-fluorophenyl)thiazole-4-carbaldehyde 
• 1183405-42-6 2-[4-(trifluoromethoxy)phenyl]-1,3-thiazole-4-carbaldehyde 
• 859850-99-0 2-(3-chlorophenyl)thiazole-4-carbaldehyde 
• 83053-39-8 2'-(2-hydroxyphenyl)-2'-thiazole-4'-carboxaldehyde 
• 749902-11-2 2-(3-methoxyphenyl)thiazole-4-carbaldehyde 
• 885279-11-8 2-(2-methoxyphenyl)thiazole-4-carbaldehyde 
• 174006-70-3 2-(4-(trifluoromethyl)phenyl)thiazole-4-carbaldehyde 
• 20949-81-9 2-phenyl-thiazole-4-carbaldehyde 
• 1187543-47-0 2-amino-4-(2-bromo-1,3-thiazol-4-yl)-6-sulfanylpyridine-3,5-dicarbonitrile 
• 1255940-31-8 (2-bromo-1,3-thiazol-4-yl)(3-methoxyphenyl)methanol 
• 1033865-70-1 (2-bromothiazol-4-ylmethyl)(4-fluorophenyl)amine 
• 5198-86-7 (2-bromo-1,3-thiazol-4-yl)methanol 

Relevant academic research and scientific papers

COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH NLRP ACTIVITY

In one aspect, compounds of Formula AA, or a pharmaceutically acceptable salt thereof, are featured.The variables shown in Formula AA are as defined in the claims. The compounds of formula AA are NLRP3 activity modulators and, as such, can be used in the treatment of metabolic disorders (e.g. Type 2 diabetes, atherosclerosis, obesity or gout), a disease of the central nervous system (e.g. Alzheimer's disease, multiple sclerosis, Amyotrophic Lateral Sclerosis or Parkinson's disease), lung disease (e.g. asthma, COPD or pulmonary idiopathic fibrosis), liver disease (e.g. NASH syndrome, viral hepatitis or cirrhosis), pancreatic disease (e.g. acute pancreatitis or chronic pancreatitis), kidney disease (e.g. acute kidney injury or chronic kidney injury), intestinal disease (e.g. Crohn's disease or Ulcerative Colitis), skin disease (e.g. psoriasis), musculoskeletal disease (e.g. scleroderma), a vessel disorder (e.g. giant cell arteritis), a disorder of the bones (e.g. osteoarthritis, osteoporosis or osteopetrosis disorders), eye disease (e.g. glaucoma or macular degeneration), a disease caused by viral infection (e.g. HIV or AIDS), an autoimmune disease (e.g. Rheumatoid Arthritis, Systemic Lupus Erythematosus or Autoimmune Thyroiditis), cancer or aging.

Synthesis of New 1,3-Thiazolecarbaldehydes

H-Lithiation and Br-lithiation reactions of 1,3-thiazole were studied in order to obtain new thiazole derivatives. Four isomeric chloromethyl derivatives of 1,3-thiazole containing a protected aldehyde group like 2-(1,3-dioxolan-2-yl)-5-(chloromethyl)-1,3-thiazole, 5-(1,3-dioxolan-2-yl)-2-(chloromethyl)-1,3-thiazole, 4-(1,3-dioxolan-2-yl)-2-(chloromethyl)-1,3-thiazole, and 2-(1,3-dioxolan-2-yl)-4-(chloromethyl)-1,3-thiazole were synthesized. Their nucleophilic substitution reactions with dimethylamine and sodium methylthiolate were studied. New aldehydes of 1,3-thiazole series of low-molecular weight were obtained.

COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH NLRP ACTIVITY

In one aspect, compounds of Formulae (I) and (II), or pharmaceutically acceptable salts thereof, are featured; Formula (I), Formula (II) or a pharmaceutically acceptable salt thereof, wherein the variables shown in Formulae (I) and (II) can be as defined anywhere herein.

THERAPEUTICALLY ACTIVE COMPOUNDS AND THEIR METHODS OF USE

Provided are compounds useful for treating cancer and methods of treating cancer comprising administering to a subject in need thereof a compound described herein.

THERAPEUTICALLY ACTIVE COMPOUNDS AND THEIR METHODS OF USE

Provided are compounds useful for treating cancer and methods of treating cancer comprising administering to a subject in need thereof a compound described herein.

The characterization of a novel V1b antagonist lead series

The SAR around a V1b antagonist HTS hit 3 was explored to produce a series of thiazole sulfonamides as a lead series with selectivity over the related V1 and oxytocin receptors.

Total synthesis of cystothiazole A by microwave-assisted olefin cross-metathesis

A short and convergent synthesis of the myxobacterial antibiotic cystothiazole A by a microwave-assisted olefin crossmetathesis reaction and a sequential microwave-assisted cross-metathesis/Stille coupling is described. Wiley-VCH Verlag GmbH & Co. KGaA, 2008.

BIARYL COMPOUNDS USEFUL AS AGONISTS OF THE GPR38 RECEPTOR

The present invention relates to novel biaryl derivatives such as compounds of formula (I), which have activity as agonists of the GPR38 receptor and the use of such compounds or pharmaceutical compositions thereof in the treatment of gastrointestinal dis

4-[(4-(CARBOXYETHYL) PIPERIDINYL) METHYL] PYRROLIDINES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY

3-Substituted pyrrolidines having a 4-carboxypiperidinylmethyl substituent on the 4-position of the ring are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of the chemokine receptors CCR-3 and/or CCR-5.

Asymmetric synthesis of (1R,2S,3R)-2-acetyl-4-(1,2,3,4- tetrahydroxybutyl)thiazole

Two different methods for preparing the thiazole analogue 3 of the biologically active compound (1R,2S,3R)-2-acetyl-4(5)-(1,2,3,4- tetrahydroxybutyl)imidazole 1 are reported.