848501-94-0

Basic information

• Product Name: 2-BROMO-THIAZOLE-4-CARBOXAMIDE
• Synonyms: 2-BROMO-THIAZOLE-4-CARBOXAMIDE;2-bromo-1,3-thiazole-4-carboxamide(SALTDATA: FREE);2-broMo-1,3-thiazole-4-carboxaMide;2-bromo-4-Thiazolecarboxamide
• CAS NO: 848501-94-0
• Molecular Formula: C4H3BrN2OS
• Molecular Weight: 207.05
• Mol File: 848501-94-0.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 390.7 °C at 760 mmHg
• Flash Point: 190.1 °C
• Appearance: /
• Density: 1.934 g/cm³
• Vapor Pressure: 2.61E-06mmHg at 25°C
• Refractive Index: 1.656
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C
• PKA: 14.26±0.50(Predicted)
• CAS DataBase Reference: 2-BROMO-THIAZOLE-4-CARBOXAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-BROMO-THIAZOLE-4-CARBOXAMIDE(848501-94-0)
• EPA Substance Registry System: 2-BROMO-THIAZOLE-4-CARBOXAMIDE(848501-94-0)

Safety Data

• Hazardous Substances Data: 848501-94-0(Hazardous Substances Data)

Usage

General Description

2-Bromo-thiazole-4-carboxamide is a compound with the molecular formula C6H5BrN2OS. It is a brominated derivative of thiazole-4-carboxamide and is commonly used as a building block in organic synthesis. 2-BROMO-THIAZOLE-4-CARBOXAMIDE has a wide range of applications in the pharmaceutical, agrochemical, and material industries due to its ability to react with various nucleophiles and electrophiles. Additionally, 2-bromo-thiazole-4-carboxamide has been studied for its potential biological activities and is being explored as a potential drug candidate for various diseases. Overall, this chemical serves as a versatile and important intermediate in the production of various compounds in the field of organic chemistry.

InChI:InChI=1/C4H3BrN2OS/c5-4-7-2(1-9-4)3(6)8/h1H,(H2,6,8)

Upstream product

• 100367-77-9 ethyl 2-bromothiazole-4-carboxylate 
• 1336-21-6 ammonium hydroxide 
• 5198-88-9 2-bromothiazole-4-carboxylic Acid 
• 170235-26-4 2-bromo-thiazole-4-carboxylic acid methyl ester 

Downstream Products

• 848501-90-6 2-bromothiazole-4-carbonitrile 

Relevant articles and documents

Corresponding amine nitrile and method of manufacturing thereof

The invention relates to a manufacturing method of nitrile. Compared with the prior art, the manufacturing method has the characteristics of significantly reduced using amount of an ammonia source, low environmental pressure, low energy consumption, low production cost, high purity and yield of a nitrile product and the like, and nitrile with a more complex structure can be obtained. The invention also relates to a method for manufacturing corresponding amine from nitrile.

INHIBITORS OF BRUTON'S TYROSINE KINASE

This application discloses compounds according to generic Formula I: wherein all variables are defined as described herein, which inhibit Btk. The compounds disclosed herein are useful to modulate the activity of Btk and treat diseases associated with excessive Btk activity. The compounds are further useful to treat inflammatory and auto immune diseases associated with aberrant B-cell proliferation such as rheumatoid arthritis. Also disclosed are compositions containing compounds of Formula I and at least one carrier, diluent or excipient.

NUCLEAR TRANSPORT MODULATIORS AND USES THEREOF

The invention generally relates to the field of nuclear transport modulators, e.g., CRM1 inhibitors, and more particularly to new substituted-heterocyclic azole compounds, the synthesis and use of these compounds and their pharmaceutical compositions, e.g