51985-33-2Relevant academic research and scientific papers
The site-selective functionalization of halogen-bearing phenols: An exercise in diversity-oriented organometallic synthesis
Marzi, Elena,Schlosser, Manfred
, p. 3393 - 3401 (2007/10/03)
The organometallic approach to diversity-oriented organic synthesis was subjected to a further test, this time in the phenol series. The model compounds selected were 2,3,6-trifluorophenol, the three isomers of (trifluoromethoxy) phenol and the three isomers of chlorophenol. A combination of optionally site selective metalations and protective group-controlled metalations enabled the selective generation of several isomeric intermediates in each case and their subsequent conversion into functionalized derivatives, in particular hydroxybenzoic acids.
