51991-28-7

Basic information

• Product Name: Benzene, 1-bromo-4-(2,2-dimethylpropyl)-
• CAS NO: 51991-28-7
• Molecular Formula: C11H15Br
• Molecular Weight: 227.144
• Mol File: 51991-28-7.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Benzene, 1-bromo-4-(2,2-dimethylpropyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1-bromo-4-(2,2-dimethylpropyl)-(51991-28-7)
• EPA Substance Registry System: Benzene, 1-bromo-4-(2,2-dimethylpropyl)-(51991-28-7)

Safety Data

• Hazardous Substances Data: 51991-28-7(Hazardous Substances Data)

Upstream product

• 1007-26-7 (2,2-dimethyl-1-propyl)benzene 
• 507-19-7 t-butyl bromide 
• 1122-91-4 4-bromo-benzaldehyde 
• 558-17-8 tert-Butyl iodide 
• 57477-93-7 hydrazone of p-bromobenzaldehyde 
• 106-37-6 1.4-dibromobenzene 
• 630-18-2 tert-butyl isocyanide 
• 49660-93-7 4'-bromoisobutyrophenone 
• 10342-83-3 4'-Bromopropiophenone 
• 594-19-4 tert.-butyl lithium 
• 589-17-3 p-bromobenzyl chloride 
• 30314-45-5 1-(4-bromophenyl)-2,2-dimethylpropan-1-one 

Downstream Products

• 120173-34-4 1-<(S)-hydroxy<(1R,3S)-1,2,2,3-tetramethylcyclopentyl>methyl>-4-neopentylbenzene 
• 1025014-22-5 2,3,4,5-tetrakis(4-tert-butylphenyl)thiophene 
• 120173-37-7 1-<(ξ)-chloro<(1S,3S)-1,2,2,3-tetramethylcyclopentyl>methyl>-4-neopentylbenzene 
• 120173-40-2 4-neopentyl-1-<<(1S,3S)-1,2,2,3-tetramethylcyclopentyl>methyl>benzene 
• 2415-90-9 -trimethyl-silan 

Relevant articles and documents

THERAPEUTIC COMPOUNDS

The present disclosure relates to compounds of formula (I) and pharmaceutically acceptable salts thereof, and compositions and uses thereof. The compounds are useful as inhibitors of the YAP:TEAD protein:protein interaction. Also included are pharmaceutical compositions comprising a compound of formula (I) or a pharmaceutically acceptable salt thereof, and methods of using such compounds and salts in the treatment of various YAP:TEAD-mediated disorders, including cancer.

Nickel-Catalyzed Cross-Coupling of Umpolung Carbonyls and Alkyl Halides

An effective nickel-catalyzed cross-coupling of Umpolung carbonyls and alkyl halides was developed. Complementary to classical alkylation techniques, this reaction utilizes Umpolung carbonyls as the environmentally benign alkyl nucleophiles, providing an efficient and selective catalytic alternative to the traditional use of highly reactive alkyl organometallic reagents.