30314-45-5

Basic information

• Product Name: 4'-BROMO-2,2-DIMETHYLPROPIOPHENONE
• Synonyms: 4'-BROMO-2,2-DIMETHYLPROPIOPHENONE;OTAVA-BB 1043866;UKRORGSYN-BB BBV-5118730
• CAS NO: 30314-45-5
• Molecular Formula: C₁₁H₁₃BrO
• Molecular Weight: 241.12
• Mol File: 30314-45-5.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 293.4°C at 760 mmHg
• Flash Point: 50.4°C
• Appearance: /
• Density: 1.291g/cm³
• Vapor Pressure: 0.00173mmHg at 25°C
• Refractive Index: 1.531
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 4'-BROMO-2,2-DIMETHYLPROPIOPHENONE(CAS DataBase Reference)
• NIST Chemistry Reference: 4'-BROMO-2,2-DIMETHYLPROPIOPHENONE(30314-45-5)
• EPA Substance Registry System: 4'-BROMO-2,2-DIMETHYLPROPIOPHENONE(30314-45-5)

Safety Data

• Hazardous Substances Data: 30314-45-5(Hazardous Substances Data)

Usage

General Description

4'-Bromo-2,2-dimethylpropiophenone is a chemical compound with the molecular formula C11H13BrO. It is a white to off-white crystalline powder with a molecular weight of 227.12 g/mol. This chemical is commonly used as an intermediate in the synthesis of various pharmaceuticals, agrochemicals, and dyes. It is also utilized as a reagent in organic synthesis and as a building block for the preparation of various derivatives. The compound is known for its mild, sweet, and floral odor, and it is important to handle it with caution as it may irritate the skin, eyes, and respiratory system. Furthermore, 4'-Bromo-2,2-dimethylpropiophenone should be stored in a cool, dry, and well-ventilated area away from incompatible materials and sources of ignition.

InChI:InChI=1/C11H13BrO/c1-11(2,3)10(13)8-4-6-9(12)7-5-8/h4-7H,1-3H3

Upstream product

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• 74-88-4 methyl iodide 

Downstream Products

• 2415-90-9 -trimethyl-silan 
• 31006-99-2 3,3-dimethyl-2-(4-bromophenyl)-1-butene 

Relevant articles and documents

N-Heterocyclic Carbene-Catalyzed Decarboxylative Alkylation of Aldehydes

We found that N-heterocyclic carbene catalysis promoted the unprecedented decarboxylative coupling of aryl aldehydes and tertiary or secondary alkyl carboxylic acid-derived redox-active esters to produce aryl alkyl ketones. The mild and transition-metal-free reaction conditions are attractive features of this method. The power of this protocol was demonstrated by the functionalization of pharmaceutical drugs and natural product. A reaction pathway involving single electron transfer from an enolate form of Breslow intermediate to a redox ester followed by recombination of the resultant radical pair to form a carbon-carbon bond is proposed.

AMIDE COMPOUNDS AS TRYPTOPHAN HYDROXYLASE INHIBITORS

The present invention is directed to amide compounds which are inhibitors of tryptophan hydroxylase (TPH), particularly isoform 1 (TPH1), that are useful in the treatment or prevention of diseases or disorders associated with peripheral serotonin including, for example, gastrointestinal, cardiovascular, pulmonary, inflammatory, metabolic, fibrotic, and low bone mass diseases, as well as cancer.

Ultrasound assisted Friedel-Crafts acylation of aromatics using ferric sulphate as catalyst

The use of ultrasound in the acylation reactions of various aromatics and polyaromatics with different acyl chlorides, in the presence of catalytic amount of ferric sulphate at room temperature, gives good yields of the respective ketones with a short reaction time. A facile and simple synthesis of various aromatic ketones using Friedel-Crafts acylation has been established from the corresponding acid chlorides and aromatic or polyaromatic compounds, respectively under mild reaction conditions with shorter reaction times (30-45 min) and in reasonable yields. This method offers the advantage of low cost and ease of purification of the products because of the small amount of ferric sulphate used in these reactions.