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52-88-0

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52-88-0 Usage

Chemical Properties

mp 162-164 C

Originator

Methylatropine,Paganfarma

Uses

Different sources of media describe the Uses of 52-88-0 differently. You can refer to the following data:
1. antibacterial
2. cephalosporin antimicrobial
3. Atropine methyl nitrate has been used to suppress mucus production and respiratory secretions in rats. It has also been used to study its effects on xanomeline-induced suppression of serum tumor necrosis factor.

Manufacturing Process

There are 2 methods of synthesis of methyl atropine nitrate: 1) To a solution of 28.9 g atropine of in 100 g of methanol was added at 110°C for 2 hours 7.7 g methyl nitrate. Methanol was evaporated and methyl atropine nitrate was crystallysed, M.P. 163°C. 2) To a solution of 70.4 g methyl atropine sulfate (prepared from methyl atropine chloride and silver nitrate) in water was added aqueous solution of 26.1 g barium nitrate. Barium sulfate was deleted by filtration. Filtrate was concentrated and the methyl atropine nitrate was obtained.

Brand name

Ekomine (Hoechst-Roussel); Eumydrin (Sterling Winthrop).

Therapeutic Function

Anticholinergic, Mydriatic, Spasmolytic

Biochem/physiol Actions

Atropine methyl nitrate is a muscarinic acetylcholine receptor antagonist that does not cross the blood brain barrier. Atropine methyl nitrate has been used for its peripheral muscarinic effects (bladder, respiratory, to block parasympathetic signaling to the heart, etc.) and to separate central from peripheral effects or protect against peripheral side effects when using muscarinics that do cross the blood brain barrier.

Safety Profile

Poison by intraperitoneal, intravenous, and subcutaneous routes. Moderately toxic by ingestion. Human systemic effects: mydriasis. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx. See also ATROPINE and NITRATES.

Check Digit Verification of cas no

The CAS Registry Mumber 52-88-0 includes 5 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 2 digits, 5 and 2 respectively; the second part has 2 digits, 8 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 52-88:
(4*5)+(3*2)+(2*8)+(1*8)=50
50 % 10 = 0
So 52-88-0 is a valid CAS Registry Number.
InChI:InChI=1/C18H26NO3.NO3/c1-19(2)14-8-9-15(19)11-16(10-14)22-18(21)17(12-20)13-6-4-3-5-7-13;2-1(3)4/h3-7,14-17,20H,8-12H2,1-2H3;/q+1;-1/t14-,15+,16+,17?;

52-88-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name (8,8-dimethyl-8-azoniabicyclo[3.2.1]octan-3-yl) 3-hydroxy-2-phenylpropanoate,nitrate

1.2 Other means of identification

Product number -
Other names Harvatrate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:52-88-0 SDS

52-88-0Synthetic route

methyl bromide
74-83-9

methyl bromide

atropine
51-55-8

atropine

atropine methyl nitrate
52-88-0

atropine methyl nitrate

Conditions
ConditionsYield
With ethanol Bromid;
methyl nitrate
598-58-3

methyl nitrate

atropine
51-55-8

atropine

atropine methyl nitrate
52-88-0

atropine methyl nitrate

Conditions
ConditionsYield
With methanol at 110℃;
atropine chloromethylate

atropine chloromethylate

atropine methyl nitrate
52-88-0

atropine methyl nitrate

Conditions
ConditionsYield
With silver sulfate und behandelt das entstandene Sulfat mit Bariumnitrat oder Bleinitrat;
atropine iodomethylate

atropine iodomethylate

atropine methyl nitrate
52-88-0

atropine methyl nitrate

Conditions
ConditionsYield
With water; silver(l) oxide und neutralisiert mit Salpetersaeure;
With silver sulfate und behandelt das entstandene Sulfat mit Bariumnitrat oder Bleinitrat;
atropine iodomethylate

atropine iodomethylate

silver nitrate

silver nitrate

atropine methyl nitrate
52-88-0

atropine methyl nitrate

Conditions
ConditionsYield
With water

52-88-0Downstream Products

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