52009-05-9Relevant academic research and scientific papers
Compounds for and methods of treating diseases
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, (2021/10/27)
The present invention provides heterocyclic compounds of formula (I) that modulate biological metals and to pharmaceutical compositions containing such compounds. The invention particularly relates to compounds that modulate iron and to compounds for the treatment of diseases, particularly neurological diseases such as Parkinson's disease (PD), Alzheimer's disease (AD), Alzheimer-type dementia, Huntington's disease (HD), amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD) and multiple system atrophy (MSA).
Structure and infrared spectrum of 2-hydroxyphenyl radical
Nagata, Mitsuhiro,Futami, Yoshisuke,Akai, Nobuyuki,Kudoh, Satoshi,Nakata, Munetaka
, p. 259 - 264 (2007/10/03)
Infrared spectrum of 2-hydroxyphenyl, ·C 6H4-OH, produced from 2-iodophenol in a low-temperature argon matrix upon UV irradiation (λ>280 nm) was measured with an FT-IR spectrophotometer. This radical was found to be less stable by 120 kJ mol -1 than phenoxyl, C6H5-O·, by a density functional theory calculation. Two final photoproducts were identified as cyclopentadienylidenemethanone and 4-iodo-2,5-cyclohexadienone in analogy with the photoproducts of 2-chloro and 2-bromophenols. A kinetic analysis shows that the latter is produced via 2-hydroxyphenyl by hydrogen migration and iodine recombination while the former is produced by Wolff rearrangement after elimination of hydrogen iodide.
Thermal properties of 1,1′-bis(p-substituted-benzoyloxy-substituted-phenyl)cyclohexanes
Rajkotia,Parsania
, p. 24 - 27 (2007/10/03)
DSC thermograms of 1,1′-bis(p-substituted-benzoyloxy-substituted-phenyl)cyclohexanes 3, 8, 14 and 15 showed two endotherms whereas 2, 4-7, 9, 11-13, 16 and 17 showed more than two endotherms indicating formation of new compounds as a result of decomposition of original compound. TG thermograms of 1, 2, 4, 5, 8, 11-13 and 15 involved a single step decomposition whereas 3, 6, 7, 9, 10, 14, 16 and 17 involved two step degradation and involved first order kinetics.
