52009-44-6Relevant academic research and scientific papers
PYRROLO [2,3-B]PYRIDINE-3-CARBOXAMIDE COMPOSITIONS AND METHODS FOR AMELIORATING HEARING LOSS
-
Paragraph 00115, (2021/08/13)
N-(3-Substituted thiazol-2(3H)-ylidene)-1H-pyrrolo[2,3-b]pyridine-3-carboxamides and N-(3-substituted oxazol-2(3H)-ylidene)-1H-pyrrolo[2,3-b]pyridine-3-carboxamides (I) and (II) are disclosed. The compounds activate Yap and inhibit Lats kinases. They are therefore useful for treating hearing loss.
THIOPHENE DERIVATIVES FOR THE TREATMENT OF DISORDERS CAUSED BY IGE
-
Page/Page column 208, (2020/01/11)
Thiophene derivatives of formula (I) and a pharmaceutically acceptable salt thereof are provided. These compounds have utility for the treatment or prevention of disorders caused by IgE, such as allergy, type 1 hypersensitivity or familiar sinus inflammation.
Concise synthesis of 2-amino-4(3H)-quinazolinones from simple (hetero)aromatic amines
Zeghida, Walid,Debray, Julien,Chierici, Sabine,Dumy, Pascal,Demeunynck, Martine
, p. 2473 - 2475 (2008/09/18)
(Chemical Equation Presented) A novel and simple method of preparation of 2-alkylaminoquinazolin-4-ones with fused heteroaromatic rings from easily accessible (hetero)aromatic amines is described. The method is very efficient, and the 2-alkylaminoquinazolinone derivatives are obtained in three steps without chromatographic purification. The key step is the ring closure of the N-protected guanidine intermediates by intramolecular Friedel-Craft's type substitution.
Efficient and novel synthesis of N-Aryl-N'-ethoxycarbonylthiourea and arene-bis-ethoxycarbonylthiourea derivatives catalyzed by TMEDA
Wei, Tai-Bao,Lin, Qi,Zhang, You-Ming,Wang, Hai
, p. 2205 - 2213 (2007/10/03)
A series of N-aryl-N'-ethoxycarbonyl thioureas and arene-bis- ethoxycarbonylthiourea derivatives have been synthesized in good to excellent yields under the TMEDA catalyzed conditions at room temperature.
