52009-44-6

Basic information

• Product Name: ethyl 4-toluidinocarbothioylcarbamate
• Synonyms: ethyl 4-toluidinocarbothioylcarbamate
• CAS NO: 52009-44-6
• Molecular Formula: C₁₁H₁₄N₂O₂S
• Molecular Weight: 238.30606
• Mol File: 52009-44-6.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: ethyl 4-toluidinocarbothioylcarbamate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 4-toluidinocarbothioylcarbamate(52009-44-6)
• EPA Substance Registry System: ethyl 4-toluidinocarbothioylcarbamate(52009-44-6)

Safety Data

• Hazardous Substances Data: 52009-44-6(Hazardous Substances Data)

Upstream product

• 106-49-0 p-toluidine 
• 16182-04-0 Ethoxycarbonyl isothiocyanate 

Downstream Products

• 1015479-01-2 N-(propyl)-N'-(p-tolyl)-N''-(ethoxycarbonyl)guanidine 
• 660850-75-9 chlorobis[ethyl N-[(4-methylanilino)thiocarbonyl]carbamate-κS]copper(I) 

Relevant articles and documents

PYRROLO [2,3-B]PYRIDINE-3-CARBOXAMIDE COMPOSITIONS AND METHODS FOR AMELIORATING HEARING LOSS

N-(3-Substituted thiazol-2(3H)-ylidene)-1H-pyrrolo[2,3-b]pyridine-3-carboxamides and N-(3-substituted oxazol-2(3H)-ylidene)-1H-pyrrolo[2,3-b]pyridine-3-carboxamides (I) and (II) are disclosed. The compounds activate Yap and inhibit Lats kinases. They are therefore useful for treating hearing loss.

Concise synthesis of 2-amino-4(3H)-quinazolinones from simple (hetero)aromatic amines

(Chemical Equation Presented) A novel and simple method of preparation of 2-alkylaminoquinazolin-4-ones with fused heteroaromatic rings from easily accessible (hetero)aromatic amines is described. The method is very efficient, and the 2-alkylaminoquinazolinone derivatives are obtained in three steps without chromatographic purification. The key step is the ring closure of the N-protected guanidine intermediates by intramolecular Friedel-Craft's type substitution.

A versatile one-pot synthesis of 1,3-substituted guanidines from carbamoyl isothiocyanates

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